Condition (MeSH)
Menkes Kinky Hair Syndrome
ClinicalTrials.gov lists 9 trials for Menkes Kinky Hair Syndrome or a narrower condition beneath it. Sentynl Therapeutics, Inc. has the most among industry and government lead sponsors, with 2.
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Trials per phase
9 of the 9 trials are tagged with Menkes Kinky Hair Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Menkes Kinky Hair Syndrome trials start? (7)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 3
- Observational
Top of scale: 2
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2022 | 2 |
| 2021 | 1 |
| 2019 | 1 |
| 2018 | 1 |
| 2009 | 1 |
| 1990 | 1 |
No forecast is made for this condition: it averages 0.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Menkes Kinky Hair Syndrome trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 1/2 | 3 |
| Phase 3 | 1 |
| Observational | 3 |
| Expanded access | 1 |
How many Menkes Kinky Hair Syndrome trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 1 |
| Active, not recruiting | 2 |
| Completed | 4 |
| Approved for marketing | 1 |
| Terminated | 1 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Menkes Kinky Hair Syndrome trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Sentynl Therapeutics, Inc. | 2 |
| Cyprium Therapeutics, Inc. | 1 |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 1 |
Which serious adverse events do Menkes Kinky Hair Syndrome trials report? (2)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Death | 21 | 1 |
| Dehydration | 1 | 1 |
Which publications cover Menkes Kinky Hair Syndrome? (18)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Neurodevelopment and brain growth in classic Menkes disease is influenced by age and symptomatology at initiation of copper treatment. | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) | 2014 | Yes |
| Increased frequency of congenital heart defects in Menkes disease. | Clinical dysmorphology | 2012 | Yes |
| Favorably skewed X-inactivation accounts for neurological sparing in female carriers of Menkes disease. | Clinical genetics | 2011 | Yes |
| Molecular correlates of epilepsy in early diagnosed and treated Menkes disease. | Journal of inherited metabolic disease | 2010 | Yes |
| Translational read-through of a nonsense mutation in ATP7A impacts treatment outcome in Menkes disease. | Annals of neurology | 2009 | Yes |
Showing 5 of 18 publications.
Prevalence (12)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Menkes disease | Prevalence at birth | 1-9 / 1 000 000 | Japan | Not stated | Exact |
| Menkes disease | Prevalence at birth | 1-9 / 1 000 000 | Europe | Not stated | Exact |
| Menkes disease | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| Menkes disease | Prevalence at birth | 1-9 / 100 000 | Australia | Not stated | Exact |
| Menkes disease | Prevalence at birth | 1-9 / 100 000 | Australia | Not stated | Exact |
Showing 5 of 12 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Menkes disease | 565 | Exact | Orphadata Science knowledge files, Product 1 |
| Menkes disease | 565 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.
Not computed for conditions with fewer than 10 trials: drugs tested.