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Condition (MeSH)

Obstetric Labor, Premature

ClinicalTrials.gov lists 2,644 trials for Obstetric Labor, Premature or a narrower condition beneath it. NICHD Neonatal Research Network has the most among industry and government lead sponsors, with 41.

MeSH D007752 Urogenital Diseases C12
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Phase 1 Phase 1 72 Phase 1/2 Phase 1/2 32 Phase 2 Phase 2 97 Phase 2/3 Phase 2/3 46 Phase 3 Phase 3 143 Phase 4 Phase 4 133 Not applicable Not applicable 1,259 Observational Observational 860 Phase 1 Phase 1 72 Phase 1/2 Phase 1/2 32 Phase 2 Phase 2 97 Phase 2/3 Phase 2/3 46 Phase 3 Phase 3 143 Phase 4 Phase 4 133 Not applicable Not applicable 1,259 Observational Observational 860

Trials per phase (log scale)

1 more section with rows

228 of the 2,644 trials are tagged with Obstetric Labor, Premature itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Obstetric Labor, Premature trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 4 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 179

1990: 2 trials (Observational 1, Not applicable 1) 1991: 1 trials (Phase 2/3 1) 1992: 2 trials (Not applicable 1, Phase 3 1) 1993: 5 trials (Observational 3, Phase 3 2) 1994: 3 trials (Observational 2, Phase 2/3 1) 1995: 1 trials (Observational 1) 1996: 6 trials (Observational 1, Not applicable 2, Phase 3 1, Phase 1/2 1, Phase 1 1) 1997: 6 trials (Observational 3, Phase 4 1, Phase 3 1, Phase 2/3 1) 1998: 5 trials (Observational 3, Not applicable 1, Phase 3 1) 1999: 6 trials (Observational 2, Not applicable 2, Phase 3 1, Phase 2 1) 2000: 7 trials (Observational 1, Not applicable 3, Phase 3 1, Phase 1/2 2) 2001: 13 trials (Observational 1, Not applicable 5, Phase 4 2, Phase 3 3, Phase 2/3 1, Phase 2 1) 2002: 18 trials (Observational 4, Not applicable 4, Phase 4 4, Phase 3 3, Phase 1/2 2, Phase 1 1) 2003: 25 trials (Observational 4, Not applicable 8, Phase 4 3, Phase 3 7, Phase 2/3 1, Phase 2 2) 2004: 29 trials (Observational 5, Not applicable 12, Phase 4 3, Phase 3 4, Phase 2/3 1, Phase 2 4) 2005: 49 trials (Observational 12, Not applicable 12, Phase 4 3, Phase 3 8, Phase 2/3 1, Phase 2 8, Phase 1/2 2, Phase 1 3) 2006: 63 trials (Observational 14, Not applicable 24, Phase 4 5, Phase 3 9, Phase 2 7, Phase 1/2 1, Phase 1 3) 2007: 55 trials (Observational 19, Not applicable 17, Phase 4 8, Phase 3 4, Phase 2 3, Phase 1/2 2, Phase 1 2) 2008: 67 trials (Observational 28, Not applicable 19, Phase 4 3, Phase 3 9, Phase 2/3 3, Phase 2 3, Phase 1 2) 2009: 55 trials (Observational 24, Not applicable 19, Phase 4 4, Phase 3 1, Phase 2/3 3, Phase 1/2 1, Phase 1 3) 2010: 68 trials (Observational 23, Not applicable 25, Phase 4 5, Phase 3 6, Phase 2 5, Phase 1/2 2, Phase 1 2) 2011: 104 trials (Observational 36, Not applicable 40, Phase 4 7, Phase 3 9, Phase 2/3 1, Phase 2 4, Phase 1/2 1, Phase 1 6) 2012: 76 trials (Observational 23, Not applicable 30, Phase 4 6, Phase 3 4, Phase 2/3 1, Phase 2 8, Phase 1 4) 2013: 109 trials (Observational 43, Not applicable 43, Phase 4 4, Phase 3 5, Phase 2/3 2, Phase 2 5, Phase 1/2 2, Phase 1 5) 2014: 114 trials (Observational 41, Not applicable 50, Phase 4 5, Phase 3 5, Phase 2/3 3, Phase 2 7, Phase 1/2 1, Phase 1 2) 2015: 119 trials (Observational 40, Not applicable 54, Phase 4 6, Phase 3 8, Phase 2/3 3, Phase 2 3, Phase 1/2 1, Phase 1 4) 2016: 122 trials (Observational 39, Not applicable 59, Phase 4 6, Phase 3 10, Phase 2/3 2, Phase 2 3, Phase 1 3) 2017: 137 trials (Observational 44, Not applicable 71, Phase 4 9, Phase 3 5, Phase 2/3 5, Phase 1/2 1, Phase 1 2) 2018: 179 trials (Observational 60, Not applicable 98, Phase 4 7, Phase 3 4, Phase 2/3 1, Phase 2 4, Phase 1/2 2, Phase 1 3) 2019: 159 trials (Observational 54, Not applicable 83, Phase 4 6, Phase 3 6, Phase 2/3 1, Phase 2 3, Phase 1/2 2, Phase 1 4) 2020: 150 trials (Observational 54, Not applicable 80, Phase 4 5, Phase 3 1, Phase 2/3 2, Phase 2 3, Phase 1 5) 2021: 160 trials (Observational 54, Not applicable 89, Phase 4 6, Phase 3 5, Phase 2/3 1, Phase 2 3, Phase 1 2) 2022: 157 trials (Observational 50, Not applicable 91, Phase 4 3, Phase 3 2, Phase 2/3 1, Phase 2 5, Phase 1/2 1, Phase 1 4) 2023: 148 trials (Observational 44, Not applicable 84, Phase 4 8, Phase 2/3 4, Phase 2 4, Phase 1/2 1, Phase 1 3) 2024: 148 trials (Observational 39, Not applicable 92, Phase 4 4, Phase 3 6, Phase 2/3 2, Phase 2 2, Phase 1/2 1, Phase 1 2) 2025: 139 trials (Observational 49, Not applicable 71, Phase 4 7, Phase 3 4, Phase 2/3 1, Phase 2 3, Phase 1/2 1, Phase 1 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 122
2025 139
2024 148
2023 148
2022 157
2021 160
2020 150
2019 159
2018 179
2017 137

Showing 10 of 37 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 130 trials starting in 2026 and about 140 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 175 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 1,640 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Obstetric Labor, Premature trials in? (9)

Shown in this order: phase order.

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Trials by phase
Phase Trials
Phase 1 72
Phase 1/2 32
Phase 2 97
Phase 2/3 46
Phase 3 143
Phase 4 133
Not applicable 1,259
Observational 860
Expanded access 2

How many Obstetric Labor, Premature trials are recruiting? (11)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 133
Recruiting 250
Enrolling by invitation 18
Active, not recruiting 83
Completed 1,443

Showing 5 of 11 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Obstetric Labor, Premature trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
NICHD Neonatal Research Network 41
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 16

Which drugs are being tested for Obstetric Labor, Premature? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Atosiban 9
Retosiban 9

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Progesterone 8% 31
Nifedipine XL 25
Vaginal Progesterone 17
Indomethacin SR 17
Standard Care 16

Showing 5 of 13 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Obstetric Labor, Premature trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Stillbirth/neonatal death 5,079 1
Patent Ductus Aretriosus 631 1
Congenital anomaly 596 2
Death 487 18
Neonatal death up to 28 days 353 1

Showing 5 of 10 adverse events.

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Which publications cover Obstetric Labor, Premature? (511)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
A randomised feasibility tolerability study of aminophylline for the prevention of preterm labour. BMC pregnancy and childbirth 2025 Yes
Performance of a Maternal Abdominal Surface Electrode System for Fetal Heart Rate and Uterine Contraction Monitoring from 34 to 37 Weeks. American journal of perinatology 2024 Yes
Impact of corticosteroid exposure on preterm labor in neonates eventually born at term. Journal of perinatology : official journal of the California Perinatal Association 2024 Yes
Vaginal Progesterone for Pregnancy Prolongation After Arrested Preterm Labor: A Randomized Clinical Trial. JAMA network open 2024 Yes
Impact of suspected preterm labour in foetal cardiovascular and metabolic programming: a prospective cohort study protocol. BMJ open 2024 Yes

Showing 5 of 511 publications.

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Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

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