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Condition (MeSH)

Lymphatic Diseases

ClinicalTrials.gov lists 12,758 trials for Lymphatic Diseases or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 566.

MeSH D008206 Hemic and Lymphatic Diseases C15
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Phase 1 Phase 1 2,629 Phase 1/2 Phase 1/2 1,286 Phase 2 Phase 2 3,680 Phase 2/3 Phase 2/3 167 Phase 3 Phase 3 931 Phase 4 Phase 4 282 Not applicable Not applicable 1,656 Observational Observational 2,078 Phase 1 Phase 1 2,629 Phase 1/2 Phase 1/2 1,286 Phase 2 Phase 2 3,680 Phase 2/3 Phase 2/3 167 Phase 3 Phase 3 931 Phase 4 Phase 4 282 Not applicable Not applicable 1,656 Observational Observational 2,078

Trials per phase (log scale)

2 more sections with rows

83 of the 12,758 trials are tagged with Lymphatic Diseases itself; the rest are tagged with a narrower condition beneath it.

Get the Lymphatic Diseases report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Lymphatic Diseases trials start? (37)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 31 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access, Unknown)

Top of scale: 682

1990: 12 trials (Observational 2, Not applicable 1, Phase 2/3 1, Phase 2 6, Phase 1 2) 1991: 10 trials (Observational 2, Not applicable 1, Phase 2 5, Phase 1 2) 1992: 14 trials (Observational 2, Phase 3 2, Phase 2 7, Phase 1/2 1, Phase 1 2) 1993: 20 trials (Observational 3, Not applicable 1, Phase 4 1, Phase 3 4, Phase 2 9, Phase 1 2) 1994: 25 trials (Observational 5, Phase 3 7, Phase 2 9, Phase 1 4) 1995: 54 trials (Observational 7, Not applicable 1, Phase 4 3, Phase 3 9, Phase 2/3 2, Phase 2 19, Phase 1/2 5, Phase 1 8) 1996: 61 trials (Observational 8, Not applicable 3, Phase 4 2, Phase 3 10, Phase 2 24, Phase 1/2 2, Phase 1 12) 1997: 81 trials (Observational 8, Not applicable 5, Phase 4 1, Phase 3 16, Phase 2/3 1, Phase 2 27, Phase 1/2 4, Phase 1 19) 1998: 117 trials (Observational 9, Not applicable 5, Phase 4 1, Phase 3 16, Phase 2/3 1, Phase 2 53, Phase 1/2 8, Phase 1 24) 1999: 149 trials (Observational 12, Not applicable 7, Phase 4 1, Phase 3 20, Phase 2/3 2, Phase 2 57, Phase 1/2 11, Phase 1 39) 2000: 177 trials (Observational 15, Not applicable 17, Phase 4 5, Phase 3 25, Phase 2/3 5, Phase 2 75, Phase 1/2 12, Phase 1 23) 2001: 159 trials (Observational 13, Not applicable 14, Phase 4 4, Phase 3 21, Phase 2/3 4, Phase 2 57, Phase 1/2 15, Phase 1 31) 2002: 193 trials (Observational 17, Not applicable 15, Phase 4 3, Phase 3 17, Phase 2/3 3, Phase 2 85, Phase 1/2 20, Phase 1 33) 2003: 229 trials (Observational 16, Not applicable 19, Phase 4 9, Phase 3 37, Phase 2/3 3, Phase 2 82, Phase 1/2 30, Phase 1 33) 2004: 293 trials (Observational 26, Not applicable 22, Phase 4 7, Phase 3 25, Phase 2/3 4, Phase 2 131, Phase 1/2 19, Phase 1 59) 2005: 319 trials (Observational 41, Not applicable 24, Phase 4 6, Phase 3 25, Phase 2/3 2, Phase 2 133, Phase 1/2 32, Phase 1 56) 2006: 350 trials (Other 1, Observational 31, Not applicable 21, Phase 4 10, Phase 3 30, Phase 2/3 2, Phase 2 144, Phase 1/2 36, Phase 1 75) 2007: 382 trials (Other 1, Observational 38, Not applicable 29, Phase 4 4, Phase 3 29, Phase 2/3 2, Phase 2 136, Phase 1/2 36, Phase 1 107) 2008: 377 trials (Observational 61, Not applicable 28, Phase 4 6, Phase 3 29, Phase 2/3 9, Phase 2 127, Phase 1/2 39, Phase 1 78) 2009: 389 trials (Other 1, Observational 64, Not applicable 35, Phase 4 12, Phase 3 33, Phase 2/3 3, Phase 2 135, Phase 1/2 34, Phase 1 72) 2010: 409 trials (Observational 61, Not applicable 33, Phase 4 13, Phase 3 25, Phase 2/3 6, Phase 2 124, Phase 1/2 50, Phase 1 97) 2011: 406 trials (Observational 72, Not applicable 35, Phase 4 8, Phase 3 29, Phase 2/3 2, Phase 2 143, Phase 1/2 36, Phase 1 81) 2012: 397 trials (Observational 66, Not applicable 36, Phase 4 10, Phase 3 44, Phase 2 114, Phase 1/2 42, Phase 1 85) 2013: 380 trials (Observational 60, Not applicable 41, Phase 4 15, Phase 3 43, Phase 2/3 5, Phase 2 83, Phase 1/2 35, Phase 1 98) 2014: 396 trials (Observational 48, Not applicable 54, Phase 4 10, Phase 3 33, Phase 2/3 5, Phase 2 93, Phase 1/2 59, Phase 1 94) 2015: 445 trials (Observational 68, Not applicable 50, Phase 4 13, Phase 3 31, Phase 2/3 10, Phase 2 137, Phase 1/2 58, Phase 1 78) 2016: 546 trials (Observational 94, Not applicable 62, Phase 4 16, Phase 3 26, Phase 2/3 18, Phase 2 140, Phase 1/2 68, Phase 1 122) 2017: 533 trials (Observational 89, Not applicable 61, Phase 4 9, Phase 3 38, Phase 2/3 5, Phase 2 136, Phase 1/2 72, Phase 1 123) 2018: 553 trials (Observational 99, Not applicable 71, Phase 4 8, Phase 3 31, Phase 2/3 2, Phase 2 147, Phase 1/2 63, Phase 1 132) 2019: 566 trials (Observational 101, Not applicable 84, Phase 4 16, Phase 3 36, Phase 2/3 8, Phase 2 126, Phase 1/2 49, Phase 1 146) 2020: 595 trials (Observational 132, Not applicable 83, Phase 4 8, Phase 3 24, Phase 2/3 7, Phase 2 141, Phase 1/2 58, Phase 1 142) 2021: 682 trials (Observational 135, Not applicable 132, Phase 4 14, Phase 3 39, Phase 2/3 4, Phase 2 154, Phase 1/2 68, Phase 1 136) 2022: 676 trials (Observational 133, Not applicable 145, Phase 4 13, Phase 3 36, Phase 2/3 5, Phase 2 132, Phase 1/2 70, Phase 1 142) 2023: 669 trials (Observational 153, Not applicable 134, Phase 4 14, Phase 3 36, Phase 2/3 7, Phase 2 129, Phase 1/2 73, Phase 1 123) 2024: 680 trials (Observational 146, Not applicable 134, Phase 4 16, Phase 3 26, Phase 2/3 8, Phase 2 188, Phase 1/2 53, Phase 1 109) 2025: 656 trials (Observational 127, Not applicable 120, Phase 4 15, Phase 3 31, Phase 2/3 17, Phase 2 176, Phase 1/2 62, Phase 1 108)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 590
2025 656
2024 680
2023 669
2022 676
2021 682
2020 595
2019 566
2018 553
2017 533

Forecast of the full-year count, planned starts included, not rows of this table: about 740 trials starting in 2026 and about 670 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 10 percent and ran about 4 percent high against the count later registered; forecasts made before the year began were off by about 25 percent and ran about 15 percent low against the count later registered, and had about 7 percent more error than repeating last year's count. The part-way figures are from forecasts that used a multiple fitted only on earlier years. A stricter check that trains only on older years did not support adding planned starts for conditions of this size: it ran about 6 percent high against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 1,576 trials still running at the 2026-10-09 snapshot; registered median of 39 months across 7,452 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Lymphatic Diseases trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 2,629
Phase 1/2 1,286
Phase 2 3,680
Phase 2/3 167
Phase 3 931
Phase 4 282
Not applicable 1,656
Observational 2,078
Expanded access 47
Unknown 2

How many Lymphatic Diseases trials are recruiting? (13)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 506
Recruiting 1,833
Enrolling by invitation 71
Active, not recruiting 907
Available 14

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Lymphatic Diseases trials? (5)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 566
Hoffmann-La Roche 126
Novartis Pharmaceuticals 117
Children's Oncology Group 114
Celgene 81

Which drugs are being tested for Lymphatic Diseases? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
RITUXIMAB 1,218
Cytoxan 1,182
Prednisone 452
IBRUTINIB 230

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
SQ Fludarabine 642
Vincristina 572
Doxorubicine 521
Etoposid 473
Cytarabine IT 435

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Lymphatic Diseases trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Febrile neutropenia 6,414 713
Pneumonia 5,465 681
Neutrophil count decreased 3,481 273
Pyrexia 3,415 523
Sepsis 3,011 699

Which publications cover Lymphatic Diseases? (93)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (13)

MeSH descendants one level down with at least one trial, most trials first.

+3 more sub-conditions

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages