Condition (MeSH)
Malignant Hyperthermia
ClinicalTrials.gov lists 12 trials for Malignant Hyperthermia or a narrower condition beneath it.
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Trials per phase
12 of the 12 trials are tagged with Malignant Hyperthermia itself; the rest are tagged with a narrower condition beneath it.
When did Malignant Hyperthermia trials start? (10)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Not applicable
- Observational
Top of scale: 2
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2025 | 1 |
| 2023 | 1 |
| 2022 | 2 |
| 2021 | 1 |
| 2020 | 2 |
| 2019 | 1 |
| 2018 | 1 |
| 2015 | 1 |
| 2012 | 1 |
| 2006 | 1 |
No forecast is made for this condition: it averages 0.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 12 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Malignant Hyperthermia trials in? (2)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Not applicable | 1 |
| Observational | 11 |
How many Malignant Hyperthermia trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 1 |
| Completed | 3 |
| Terminated | 1 |
| Withdrawn | 2 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Interventions as named in the registry (1)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Data analysis | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Malignant Hyperthermia? (25)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| The neuromuscular and multisystem features of RYR1-related malignant hyperthermia and rhabdomyolysis: A study protocol. | Medicine | 2021 | Yes |
| Bayesian modeling to predict malignant hyperthermia susceptibility and pathogenicity of <i>RYR1</i>, <i>CACNA1S</i> and <i>STAC3</i> variants. | Pharmacogenomics | 2019 | Yes |
| Anesthesia-induced rhabdomyolysis or malignant hyperthermia: is defining the crisis important? | Paediatric anaesthesia | 2017 | Yes |
| Perioperative thermoregulation and heat balance. | Lancet (London, England) | 2016 | Yes |
| An RYR1 mutation associated with malignant hyperthermia is also associated with bleeding abnormalities. | Science signaling | 2016 | Yes |
Showing 5 of 25 publications.
Prevalence (3)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Malignant hyperthermia of anesthesia | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| Malignant hyperthermia of anesthesia | Point prevalence | Unknown | Worldwide | Not stated | Unspecified |
| Malignant hyperthermia of anesthesia | Point prevalence | Unknown | Worldwide | Not stated | Exact |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Malignant hyperthermia of anesthesia | 423 | Exact | Orphadata Science knowledge files, Product 1 |
| Malignant hyperthermia of anesthesia | 423 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, serious adverse events in this condition's trials, and sub-conditions in mesh.