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Condition (MeSH)

Maxillofacial Injuries

ClinicalTrials.gov lists 144 trials for Maxillofacial Injuries or a narrower condition beneath it. Stryker Craniomaxillofacial has the most among industry and government lead sponsors, with 4.

MeSH D008446 Nervous System Diseases C10 C26
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Phase 1 Phase 1 1 Phase 1/2 Phase 1/2 1 Phase 2 Phase 2 3 Phase 2/3 Phase 2/3 2 Phase 3 Phase 3 5 Phase 4 Phase 4 4 Not applicable Not applicable 89 Observational Observational 38 Phase 1 Phase 1 1 Phase 1/2 Phase 1/2 1 Phase 2 Phase 2 3 Phase 2/3 Phase 2/3 2 Phase 3 Phase 3 5 Phase 4 Phase 4 4 Not applicable Not applicable 89 Observational Observational 38

Trials per phase (log scale)

1 more section with rows

20 of the 144 trials are tagged with Maxillofacial Injuries itself; the rest are tagged with a narrower condition beneath it.

Get the Maxillofacial Injuries report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Maxillofacial Injuries trials start? (21)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Expanded access)

Top of scale: 25

2004: 2 trials (Not applicable 1, Phase 2 1) 2006: 1 trials (Phase 4 1) 2007: 3 trials (Observational 3) 2008: 2 trials (Other 1, Observational 1) 2010: 1 trials (Phase 3 1) 2011: 3 trials (Observational 1, Not applicable 1, Phase 3 1) 2012: 1 trials (Not applicable 1) 2013: 2 trials (Not applicable 1, Phase 2 1) 2014: 6 trials (Observational 2, Not applicable 3, Phase 3 1) 2015: 2 trials (Not applicable 2) 2016: 6 trials (Observational 3, Not applicable 3) 2017: 5 trials (Observational 2, Not applicable 3) 2018: 7 trials (Observational 3, Not applicable 4) 2019: 15 trials (Observational 4, Not applicable 11) 2020: 12 trials (Observational 4, Not applicable 6, Phase 2/3 1, Phase 1 1) 2021: 9 trials (Observational 2, Not applicable 5, Phase 2/3 1, Phase 1/2 1) 2022: 6 trials (Observational 1, Not applicable 5) 2023: 9 trials (Observational 2, Not applicable 6, Phase 4 1) 2024: 25 trials (Observational 6, Not applicable 15, Phase 4 2, Phase 3 2) 2025: 16 trials (Observational 3, Not applicable 13)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 11
2025 16
2024 25
2023 9
2022 6
2021 9
2020 12
2019 15
2018 7
2017 5

Forecast of the full-year count, planned starts included, not rows of this table: about 14 trials starting in 2026 and about 17 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 33 months from start to primary completion across 12 trials still running at the 2026-10-09 snapshot; registered median of 16 months across 78 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Maxillofacial Injuries trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1
Phase 1/2 1
Phase 2 3
Phase 2/3 2
Phase 3 5
Phase 4 4
Not applicable 89
Observational 38
Expanded access 1

How many Maxillofacial Injuries trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 12
Recruiting 8
Enrolling by invitation 4
Active, not recruiting 6
Completed 69

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Maxillofacial Injuries trials? (3)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Stryker Craniomaxillofacial 4
Instituto Mexicano del Seguro Social 3
Global D 2

Which drugs are being tested for Maxillofacial Injuries? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Vitamin C 2
Nitroglycerin 1
METHYLPREDNISOLONE 1

Interventions as named in the registry (10)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Control (placebo) group 1
AlloDerm 1
Application of autologous mesenchymal stem cells 1
Different post-operative antibiotic regimens following surgical treatment of mandible fractures 1
TREATMENT 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Maxillofacial Injuries trials report? (1)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Postoperative Infection 2 1

Which publications cover Maxillofacial Injuries? (52)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
A clinical decision aid for patients with suspected midfacial and mandibular fractures (the REDUCTION-I study): a prospective multicentre cohort study. European journal of trauma and emergency surgery : official publication of the European Trauma Society 2022 Yes
Analysis of Maxillofacial Fractures Based on the Etiology in Southeast China: A 10-Year, Multi-Center Study. The Journal of craniofacial surgery 2021 Yes
Do the Benefits of Systemic Corticosteroids Outweigh Adverse Effects During Maxillofacial Trauma Surgery? A Systematic Review and Meta-Analysis. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2021 Yes
Autologous Fat Transfer for Maxillofacial Reconstruction. Atlas of the oral and maxillofacial surgery clinics of North America 2018 Yes
Use of patient-reported outcome measures in oral and maxillofacial trauma surgery: a review. The British journal of oral & maxillofacial surgery 2018 Yes

Sub-conditions in MeSH (4)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages