Condition (MeSH)
Methemoglobinemia
ClinicalTrials.gov lists 12 trials for Methemoglobinemia or a narrower condition beneath it. NICHD Neonatal Research Network has the most among industry and government lead sponsors, with 2.
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Trials per phase
12 of the 12 trials are tagged with Methemoglobinemia itself; the rest are tagged with a narrower condition beneath it.
When did Methemoglobinemia trials start? (11)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 3
- Not applicable
- Observational
Top of scale: 2
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2025 | 1 |
| 2024 | 1 |
| 2019 | 1 |
| 2018 | 1 |
| 2012 | 1 |
| 2011 | 2 |
| 2009 | 1 |
| 2008 | 1 |
| 2005 | 1 |
| 1998 | 1 |
Showing 10 of 11 earlier years.
No forecast is made for this condition: it averages 0.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 12 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Methemoglobinemia trials in? (4)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 3 |
| Phase 3 | 2 |
| Not applicable | 1 |
| Observational | 6 |
How many Methemoglobinemia trials are recruiting? (2)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Completed | 10 |
| Terminated | 2 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Methemoglobinemia trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| NICHD Neonatal Research Network | 2 |
| American Regent, Inc. | 1 |
| National Institute of Neurological Disorders and Stroke (NINDS) | 1 |
| Nonin Medical, Inc | 1 |
Which drugs are being tested for Methemoglobinemia? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Methylene Blue | 2 |
| Dapsone | 1 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Inhaled Nitric Oxide (iNO) use | 2 |
| AG chemotherapy | 1 |
| Met-Hb | 1 |
| Standard iNO therapy | 1 |
| leucocytes | 1 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Methemoglobinemia? (38)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Ferric Carboxymaltose-mediated Methemoglobinemia. | Current drug safety | 2024 | Yes |
| Methemoglobinaemia after diagnostic hystero-laparoscopic chromopertubation in a sub-fertile patient. | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology | 2019 | Yes |
| Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial. | BMC pediatrics | 2016 | Yes |
| Neuroprotective efficacy of methylene blue in ischemic stroke: an MRI study. | PloS one | 2013 | Yes |
| Accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia. | Anesthesia and analgesia | 2010 | Yes |
Showing 5 of 38 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.