Condition (MeSH)
Mitral Valve Prolapse
ClinicalTrials.gov lists 47 trials for Mitral Valve Prolapse or a narrower condition beneath it.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
47 of the 47 trials are tagged with Mitral Valve Prolapse itself; the rest are tagged with a narrower condition beneath it.
When did Mitral Valve Prolapse trials start? (21)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Not applicable
- Observational
Top of scale: 4
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2025 | 4 |
| 2024 | 3 |
| 2023 | 4 |
| 2022 | 1 |
| 2021 | 3 |
| 2020 | 2 |
| 2018 | 4 |
| 2017 | 1 |
| 2016 | 4 |
Showing 10 of 21 earlier years.
No forecast is made for this condition: it averages 2.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Mitral Valve Prolapse trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 2 |
| Phase 1/2 | 1 |
| Phase 2 | 1 |
| Phase 3 | 1 |
| Not applicable | 17 |
| Observational | 25 |
How many Mitral Valve Prolapse trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 8 |
| Active, not recruiting | 3 |
| Completed | 20 |
| Terminated | 2 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Mitral Valve Prolapse trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Abbott Medical Devices | 5 |
| Edwards Lifesciences | 5 |
| NeoChord | 4 |
Which drugs are being tested for Mitral Valve Prolapse? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Flecainide | 1 |
Interventions as named in the registry (3)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Metoprolol XL | 1 |
| Blood collection | 1 |
| Blood Biomarkers | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Mitral Valve Prolapse trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Death | 546 | 4 |
| Congestive heart failure | 361 | 3 |
| Other | 144 | 2 |
| Atrial arrhythmia | 131 | 3 |
| Pneumonia | 127 | 4 |
Showing 5 of 10 adverse events.
Which publications cover Mitral Valve Prolapse? (64)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Right Ventricular Response to Hypercapnia After Mitral Valve Repair: A Hemodynamic Assessment. | Acta anaesthesiologica Scandinavica | 2025 | Yes |
| Machine Learning-Based Phenogrouping in MVP Identifies Profiles Associated With Myocardial Fibrosis and Cardiovascular Events. | JACC. Cardiovascular imaging | 2023 | Yes |
| Morphology of Mitral Annular Disjunction in Mitral Valve Prolapse. | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography | 2022 | Yes |
| Definition, prevalence, and clinical significance of mitral annular disjunction in different patient cohorts: A systematic review. | Echocardiography (Mount Kisco, N.Y.) | 2022 | Yes |
| Genetic background of mitral valve prolapse. | Reviews in cardiovascular medicine | 2022 | Yes |
Showing 5 of 64 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.