Condition (MeSH)
Muscle Hypotonia
ClinicalTrials.gov lists 66 trials for Muscle Hypotonia or a narrower condition beneath it. Algenis SpA has the most among industry and government lead sponsors, with 1.
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Trials per phase (log scale)
66 of the 66 trials are tagged with Muscle Hypotonia itself; the rest are tagged with a narrower condition beneath it.
When did Muscle Hypotonia trials start? (19)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 4
- Not applicable
- Observational
Top of scale: 8
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 4 |
| 2025 | 2 |
| 2024 | 5 |
| 2022 | 4 |
| 2021 | 5 |
| 2020 | 2 |
| 2019 | 3 |
| 2018 | 8 |
| 2017 | 5 |
| 2016 | 4 |
Showing 10 of 19 earlier years.
No forecast is made for this condition: it averages 2.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 3 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Muscle Hypotonia trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 3 |
| Phase 1/2 | 2 |
| Phase 2 | 3 |
| Phase 3 | 1 |
| Phase 4 | 8 |
| Not applicable | 28 |
| Observational | 21 |
How many Muscle Hypotonia trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 3 |
| Recruiting | 7 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 1 |
| Completed | 37 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Muscle Hypotonia trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Algenis SpA | 1 |
Which drugs are being tested for Muscle Hypotonia? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Esmeron | 9 |
| PROPOFOL | 4 |
| Succinylcholine | 2 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| NMBA - cisatracurium | 3 |
| Sugamadex | 2 |
| Administration of intravenous HRS-9190 | 1 |
| Neuromuscular Blocking Agent | 1 |
| Antidepressant | 1 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Muscle Hypotonia trials report? (2)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Septic Shock | 1 | 1 |
| Small intestinal obstruction | 1 | 1 |
Which publications cover Muscle Hypotonia? (85)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Long-Term Efficacy of T3 Analogue Triac in Children and Adults With MCT8 Deficiency: A Real-Life Retrospective Cohort Study. | The Journal of clinical endocrinology and metabolism | 2022 | Yes |
| A recurrent single-exon deletion in TBCK might be under-recognized in patients with infantile hypotonia and psychomotor delay. | Human mutation | 2022 | Yes |
| Early infantile epileptic encephalopathy due to biallelic pathogenic variants in PIGQ: Report of seven new subjects and review of the literature. | Journal of inherited metabolic disease | 2020 | Yes |
| Effectiveness and safety of the tri-iodothyronine analogue Triac in children and adults with MCT8 deficiency: an international, single-arm, open-label, phase 2 trial. | The lancet. Diabetes & endocrinology | 2019 | Yes |
| REM Sleep without atonia correlates with abnormal vestibular-evoked myogenic potentials in isolated REM sleep behavior disorder. | Sleep | 2019 | Yes |
Showing 5 of 85 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.