Condition (MeSH)
Myotonia
ClinicalTrials.gov lists 14 trials for Myotonia or a narrower condition beneath it.
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Trials per phase
14 of the 14 trials are tagged with Myotonia itself; the rest are tagged with a narrower condition beneath it.
When did Myotonia trials start? (7)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1/2
- Phase 2
- Phase 3
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 5 |
| 2024 | 2 |
| 2020 | 1 |
| 2013 | 1 |
| 2008 | 2 |
| 2006 | 1 |
No forecast is made for this condition: it averages 1.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 26 months across 5 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Myotonia trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1/2 | 1 |
| Phase 2 | 2 |
| Phase 3 | 5 |
| Not applicable | 2 |
| Observational | 4 |
How many Myotonia trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 4 |
| Enrolling by invitation | 3 |
| Active, not recruiting | 1 |
| Completed | 4 |
| Terminated | 1 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Myotonia trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Avidity Biosciences, Inc. | 2 |
| Vertex Pharmaceuticals Incorporated | 2 |
| Dyne Therapeutics | 1 |
| Lupin Ltd. | 1 |
| National Institute of Neurological Disorders and Stroke (NINDS) | 1 |
Which drugs are being tested for Myotonia? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Mexiletine | 2 |
| DYNE-101 | 1 |
Interventions as named in the registry (5)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| VX-670 | 2 |
| Lamotrigine use | 1 |
| Del-desiran (AOC 1001) | 1 |
| Granular powder in unit dose foil-lined sachet Mexiletine (PR) | 1 |
| AOC 1001 | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Myotonia trials report? (1)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Drug withdrawal | 1 | 1 |
Which publications cover Myotonia? (15)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Drug treatment for myotonia. | The Cochrane database of systematic reviews | 2025 | Yes |
| Clinical features and genetic spectrum of a multicenter Chinese cohort with myotonic dystrophy type 1. | Orphanet journal of rare diseases | 2024 | Yes |
| Muscle fat replacement and contractility in patients with skeletal muscle sodium channel disorders. | Scientific reports | 2023 | Yes |
| Effect of Mexiletine on Muscle Stiffness in Patients With Nondystrophic Myotonia Evaluated Using Aggregated N-of-1 Trials. | JAMA | 2018 | Yes |
| Combined N-of-1 trials to investigate mexiletine in non-dystrophic myotonia using a Bayesian approach; study rationale and protocol. | BMC neurology | 2015 | Yes |
Showing 5 of 15 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.