Condition (MeSH)
Narcolepsy
ClinicalTrials.gov lists 139 trials for Narcolepsy or a narrower condition beneath it. Jazz Pharmaceuticals has the most among industry and government lead sponsors, with 17.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
1 more section with rows
137 of the 139 trials are tagged with Narcolepsy itself; the rest are tagged with a narrower condition beneath it.
When did Narcolepsy trials start? (25)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 12
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 10 |
| 2025 | 9 |
| 2024 | 11 |
| 2023 | 8 |
| 2022 | 5 |
| 2021 | 12 |
| 2020 | 8 |
| 2019 | 9 |
| 2018 | 3 |
| 2017 | 3 |
Showing 10 of 25 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 12 trials starting in 2026 and about 10 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 28 months from start to primary completion across 15 trials still running at the 2026-10-09 snapshot; registered median of 20 months across 90 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Narcolepsy trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 16 |
| Phase 1/2 | 1 |
| Phase 2 | 21 |
| Phase 2/3 | 2 |
| Phase 3 | 32 |
| Phase 4 | 4 |
| Not applicable | 29 |
| Observational | 32 |
| Expanded access | 2 |
How many Narcolepsy trials are recruiting? (10)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 22 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 1 |
| Completed | 93 |
Showing 5 of 10 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Narcolepsy trials? (10)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Jazz Pharmaceuticals | 17 |
| Cephalon | 7 |
| Axsome Therapeutics, Inc. | 5 |
| Alkermes, Inc. | 4 |
| Harmony Biosciences Management, Inc. | 4 |
Showing 5 of 10 sponsors.
Which drugs are being tested for Narcolepsy? (8)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Modafinil | 10 |
| Pitolisant | 9 |
| Sodium Oxybate | 7 |
| Solriamfetol | 7 |
| Armodafinil | 4 |
Showing 5 of 8 drugs.
Interventions as named in the registry (7)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| AXS-12 (Reboxetine) | 3 |
| MK-6552 | 3 |
| E2086 | 2 |
| JZP-258 | 2 |
| FT218 | 2 |
Showing 5 of 7 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Narcolepsy trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Surgeries/Procedures | 30 | 1 |
| Hospital Admissions | 8 | 1 |
| Emergency Department Visits | 7 | 1 |
| Inpatient hospitalization | 7 | 1 |
| Chest Pain | 6 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Narcolepsy? (190)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Feasibility and efficacy of exercise training on sleep symptoms and comorbidities in narcolepsy type 1: a prospective interventional study. | Sleep | 2026 | Yes |
| Effort/reward imbalance and comorbidities burden in academic and professional careers of patients with narcolepsy type 1. | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine | 2025 | Yes |
| Assessing Early Efficacy After Initiation of Once-Nightly Sodium Oxybate (ON-SXB; FT218) in Participants with Narcolepsy Type 1 or 2: A Post Hoc Analysis from the Phase 3 REST-ON Trial. | CNS drugs | 2025 | Yes |
| Efficacy of Once-Nightly Sodium Oxybate in Patients with Narcolepsy: Post Hoc Analyses of Sensitivity, Effect Size, and Numbers Needed to Treat from the Phase 3 REST-ON Trial. | CNS drugs | 2025 | Yes |
| Oveporexton, an Oral Orexin Receptor 2-Selective Agonist, in Narcolepsy Type 1. | The New England journal of medicine | 2025 | Yes |
Showing 5 of 190 publications.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Narcolepsy | 619284 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Narcolepsy | 619284 | Exact | Orphadata Science knowledge files, Product 1 |
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence.