Condition (MeSH)
Orbital Diseases
ClinicalTrials.gov lists 345 trials for Orbital Diseases or a narrower condition beneath it. Amgen has the most among industry and government lead sponsors, with 14.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase
1 more section with rows
6 of the 345 trials are tagged with Orbital Diseases itself; the rest are tagged with a narrower condition beneath it.
When did Orbital Diseases trials start? (31)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 37
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 42 |
| 2025 | 28 |
| 2024 | 37 |
| 2023 | 26 |
| 2022 | 21 |
| 2021 | 21 |
| 2020 | 17 |
| 2019 | 11 |
| 2018 | 8 |
| 2017 | 15 |
Showing 10 of 31 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 49 trials starting in 2026 and about 35 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 44 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 171 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Orbital Diseases trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 23 |
| Phase 1/2 | 13 |
| Phase 2 | 34 |
| Phase 2/3 | 13 |
| Phase 3 | 52 |
| Phase 4 | 37 |
| Not applicable | 73 |
| Observational | 99 |
| Expanded access | 1 |
How many Orbital Diseases trials are recruiting? (10)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 26 |
| Recruiting | 70 |
| Enrolling by invitation | 4 |
| Active, not recruiting | 13 |
| Completed | 151 |
Showing 5 of 10 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Orbital Diseases trials? (7)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Amgen | 14 |
| Immunovant Sciences GmbH | 9 |
| Viridian Therapeutics, Inc. | 9 |
| Innovent Biologics (Suzhou) Co. Ltd. | 6 |
| Minghui Pharmaceutical (Hangzhou) Ltd | 6 |
Showing 5 of 7 sponsors.
Which drugs are being tested for Orbital Diseases? (10)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| METHYLPREDNISOLONE | 20 |
| Methimazole | 17 |
| Teprotumumab | 12 |
| RITUXIMAB | 6 |
| Batoclimab | 5 |
Showing 5 of 10 drugs.
Interventions as named in the registry (5)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| IBI311 | 8 |
| Glucocorticoids | 4 |
| MHB018A injection | 4 |
| tocilizumab SC | 4 |
| Efgartigimod PH20 (ARGX-113) SC | 4 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Orbital Diseases trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Endocrine ophthalmopathy | 5 | 5 |
| Graves' disease | 4 | 3 |
| Optic neuropathy | 4 | 4 |
| Syncope | 3 | 2 |
| Abdominal pain | 2 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Orbital Diseases? (30)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| One-Year Patient Survival After COVID-19-Associated Rhino-Orbital-Cerebral Mucormycosis: A Multicenter Study. | Mycopathologia | 2025 | Yes |
| Evaluation of graded recession of inferior oblique muscle for correction of different grades of V-pattern strabismus. | BMC ophthalmology | 2023 | Yes |
| Orbital complications of paranasal sinusitis in Taiwan, 1988 through 2015: Acute ophthalmological manifestations, diagnosis, and management. | PloS one | 2017 | Yes |
| Fornix triamcinolone injection for thyroid orbitopathy. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie | 2015 | Yes |
| Prostaglandin associated periorbitopathy in patients using bimatoprost, latanoprost and travoprost. | Clinical & experimental ophthalmology | 2014 | Yes |
Showing 5 of 30 publications.
Sub-conditions in MeSH (5)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.