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Condition (MeSH)

Pre-Eclampsia

ClinicalTrials.gov lists 880 trials for Pre-Eclampsia or a narrower condition beneath it.

MeSH D011225 Urogenital Diseases C12 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 26 Phase 1/2 Phase 1/2 14 Phase 2 Phase 2 32 Phase 2/3 Phase 2/3 10 Phase 3 Phase 3 51 Phase 4 Phase 4 68 Not applicable Not applicable 278 Observational Observational 401 Phase 1 Phase 1 26 Phase 1/2 Phase 1/2 14 Phase 2 Phase 2 32 Phase 2/3 Phase 2/3 10 Phase 3 Phase 3 51 Phase 4 Phase 4 68 Not applicable Not applicable 278 Observational Observational 401

Trials per phase (log scale)

880 of the 880 trials are tagged with Pre-Eclampsia itself; the rest are tagged with a narrower condition beneath it.

Get the Pre-Eclampsia report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Pre-Eclampsia trials start? (32)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 68

1990: 1 trials (Observational 1) 1991: 1 trials (Phase 3 1) 1993: 1 trials (Phase 2 1) 1995: 2 trials (Observational 1, Not applicable 1) 1999: 3 trials (Observational 3) 2000: 3 trials (Observational 1, Not applicable 2) 2001: 4 trials (Not applicable 2, Phase 2/3 1, Phase 2 1) 2002: 6 trials (Observational 2, Not applicable 1, Phase 3 2, Phase 1/2 1) 2003: 9 trials (Observational 5, Phase 3 3, Phase 1 1) 2004: 10 trials (Observational 5, Not applicable 1, Phase 3 1, Phase 2 2, Phase 1/2 1) 2005: 9 trials (Observational 5, Not applicable 1, Phase 4 1, Phase 3 1, Phase 2 1) 2006: 12 trials (Observational 7, Not applicable 2, Phase 2 2, Phase 1 1) 2007: 8 trials (Observational 7, Not applicable 1) 2008: 16 trials (Observational 7, Not applicable 5, Phase 4 1, Phase 2 1, Phase 1/2 1, Phase 1 1) 2009: 23 trials (Observational 13, Not applicable 4, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 1, Phase 1 1) 2010: 16 trials (Observational 9, Not applicable 6, Phase 3 1) 2011: 14 trials (Observational 4, Not applicable 3, Phase 4 3, Phase 3 3, Phase 2 1) 2012: 26 trials (Observational 11, Not applicable 7, Phase 4 2, Phase 3 2, Phase 2 1, Phase 1/2 2, Phase 1 1) 2013: 26 trials (Observational 12, Not applicable 7, Phase 4 1, Phase 3 4, Phase 2 2) 2014: 28 trials (Observational 12, Not applicable 8, Phase 4 3, Phase 3 2, Phase 2 1, Phase 1/2 1, Phase 1 1) 2015: 49 trials (Observational 22, Not applicable 15, Phase 4 4, Phase 3 3, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 1) 2016: 43 trials (Observational 26, Not applicable 8, Phase 4 6, Phase 3 1, Phase 2/3 1, Phase 2 1) 2017: 49 trials (Observational 24, Not applicable 11, Phase 4 5, Phase 3 1, Phase 2/3 4, Phase 2 2, Phase 1 2) 2018: 47 trials (Observational 20, Not applicable 17, Phase 4 3, Phase 3 2, Phase 2/3 1, Phase 2 2, Phase 1 2) 2019: 58 trials (Observational 30, Not applicable 20, Phase 4 2, Phase 3 4, Phase 2/3 1, Phase 2 1) 2020: 46 trials (Observational 23, Not applicable 11, Phase 4 5, Phase 3 3, Phase 2 2, Phase 1/2 1, Phase 1 1) 2021: 45 trials (Observational 18, Not applicable 16, Phase 4 7, Phase 3 2, Phase 2 1, Phase 1 1) 2022: 50 trials (Observational 24, Not applicable 20, Phase 4 4, Phase 3 2) 2023: 62 trials (Observational 25, Not applicable 26, Phase 4 3, Phase 3 2, Phase 2 2, Phase 1 4) 2024: 68 trials (Observational 32, Not applicable 26, Phase 4 3, Phase 3 3, Phase 1/2 3, Phase 1 1) 2025: 64 trials (Observational 26, Not applicable 23, Phase 4 6, Phase 3 1, Phase 2 1, Phase 1/2 1, Phase 1 6)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 75
2025 64
2024 68
2023 62
2022 50
2021 45
2020 46
2019 58
2018 47
2017 49

Forecast of the full-year count, planned starts included, not rows of this table: about 90 trials starting in 2026 and about 73 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 82 trials still running at the 2026-10-09 snapshot; registered median of 23 months across 450 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Pre-Eclampsia trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 26
Phase 1/2 14
Phase 2 32
Phase 2/3 10
Phase 3 51
Phase 4 68
Not applicable 278
Observational 401

How many Pre-Eclampsia trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 63
Recruiting 127
Enrolling by invitation 9
Active, not recruiting 22
Completed 401

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Pre-Eclampsia? (6)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
PHENYLEPHRINE 8
MisoprostoL 6
LOVENOX 6
Ephedrine 6
Norepinephrine 6

Interventions as named in the registry (9)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
EC Aspirin 54
Labetolol 15
Nifedipine XL 11
IM Oxytocin 7
1% Metformin 7

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Pre-Eclampsia trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Other SAE 317 1
Fetal Death 140 1
Hypertension 63 3
Fetal Hypoxia 52 1
Neonatal death 51 4

Which publications cover Pre-Eclampsia? (1,321)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Prevalence (3)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Preeclampsia Point prevalence 1-5 / 10 000 Europe Not stated Unspecified
Preeclampsia Point prevalence 1-5 / 10 000 Europe Not stated Exact
Preeclampsia Point prevalence 1-5 / 10 000 Europe Not stated Exact

Rare-disease identity (2)

Shown in this order: exact, broader, narrower, other.

Rare-disease identity
Orphanet disease ORPHA code Relation Source
Preeclampsia 275555 Exact Orphanet Rare Disease Ontology (ORDO)
Preeclampsia 275555 Exact Orphadata Science knowledge files, Product 1

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors and sub-conditions in mesh.

Browse all condition evidence pages