Condition (MeSH)
Pseudoxanthoma Elasticum
ClinicalTrials.gov lists 32 trials for Pseudoxanthoma Elasticum or a narrower condition beneath it. University Hospital, Angers has the most among industry and government lead sponsors, with 9.
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Trials per phase
32 of the 32 trials are tagged with Pseudoxanthoma Elasticum itself; the rest are tagged with a narrower condition beneath it.
When did Pseudoxanthoma Elasticum trials start? (18)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 1 |
| 2024 | 2 |
| 2023 | 2 |
| 2022 | 5 |
| 2021 | 1 |
| 2020 | 3 |
| 2019 | 1 |
| 2018 | 4 |
| 2016 | 1 |
Showing 10 of 18 earlier years.
No forecast is made for this condition: it averages 2.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 5 trials still running at the 2026-10-09 snapshot; registered median of 29 months across 14 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Pseudoxanthoma Elasticum trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 1/2 | 2 |
| Phase 2 | 6 |
| Phase 3 | 1 |
| Phase 4 | 1 |
| Not applicable | 6 |
| Observational | 15 |
How many Pseudoxanthoma Elasticum trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 6 |
| Active, not recruiting | 3 |
| Completed | 15 |
| Withdrawn | 1 |
| Unknown status | 7 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Pseudoxanthoma Elasticum trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| University Hospital, Angers | 9 |
| Inozyme Pharma | 4 |
| Daiichi Sankyo | 2 |
| National Cancer Institute (NCI) | 1 |
| National Human Genome Research Institute (NHGRI) | 1 |
Which drugs are being tested for Pseudoxanthoma Elasticum? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| INZ-701 | 3 |
| Magnesia | 1 |
| Disodium Pyrophosphate | 1 |
Interventions as named in the registry (8)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Intravitreal injection ranibizumab | 1 |
| DS-1211b | 1 |
| 2.0 aflibercept | 1 |
| supplementary tubes | 1 |
| urine collection | 1 |
Showing 5 of 8 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Pseudoxanthoma Elasticum trials report? (1)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Circulatory collapse | 1 | 1 |
Which publications cover Pseudoxanthoma Elasticum? (65)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate. | Trials | 2025 | Yes |
| Topography of Slowed Dark Adaptation in Pseudoxanthoma Elasticum: PROPXE Study Report 1. | Investigative ophthalmology & visual science | 2025 | Yes |
| The TEMP-PREVENT trial: a study protocol for a randomized, double-blind, placebo-controlled clinical trial of etidronate for treatment in young adult patients with pseudoxanthoma elasticum. | Trials | 2025 | Yes |
| Measurement Reliability and Functional Validity of Bruch's Membrane Calcification in Pseudoxanthoma Elasticum: PROPXE Study Report 2. | Investigative ophthalmology & visual science | 2025 | Yes |
| Pseudoxanthoma elasticum - Genetics, pathophysiology, and clinical presentation. | Progress in retinal and eye research | 2024 | Yes |
Showing 5 of 65 publications.
Prevalence (3)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Pseudoxanthoma elasticum | Point prevalence | 1-9 / 100 000 | Europe | Not stated | Exact |
| Pseudoxanthoma elasticum | Point prevalence | 1-9 / 100 000 | Europe | Not stated | Exact |
| Pseudoxanthoma elasticum | Point prevalence | 1-9 / 100 000 | Europe | Not stated | Unspecified |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Pseudoxanthoma elasticum | 758 | Exact | Orphadata Science knowledge files, Product 1 |
| Pseudoxanthoma elasticum | 758 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.