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Condition (MeSH)

Psychotic Disorders

ClinicalTrials.gov lists 1,576 trials for Psychotic Disorders or a narrower condition beneath it. VA Office of Research and Development has the most among industry and government lead sponsors, with 40.

MeSH D011618 Mental Disorders F03
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Phase 1 Phase 1 92 Phase 1/2 Phase 1/2 22 Phase 2 Phase 2 128 Phase 2/3 Phase 2/3 16 Phase 3 Phase 3 125 Phase 4 Phase 4 213 Not applicable Not applicable 755 Observational Observational 225 Phase 1 Phase 1 92 Phase 1/2 Phase 1/2 22 Phase 2 Phase 2 128 Phase 2/3 Phase 2/3 16 Phase 3 Phase 3 125 Phase 4 Phase 4 213 Not applicable Not applicable 755 Observational Observational 225

Trials per phase (log scale)

1,575 of the 1,576 trials are tagged with Psychotic Disorders itself; the rest are tagged with a narrower condition beneath it.

Get the Psychotic Disorders report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Psychotic Disorders trials start? (34)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 9 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 86

1991: 1 trials (Observational 1) 1993: 1 trials (Observational 1) 1995: 2 trials (Observational 1, Phase 2 1) 1996: 1 trials (Phase 4 1) 1997: 2 trials (Not applicable 1, Phase 4 1) 1998: 6 trials (Not applicable 3, Phase 4 2, Phase 2/3 1) 1999: 5 trials (Observational 1, Phase 4 3, Phase 3 1) 2000: 17 trials (Not applicable 7, Phase 4 2, Phase 3 4, Phase 2/3 2, Phase 2 2) 2001: 30 trials (Observational 3, Not applicable 7, Phase 4 11, Phase 3 6, Phase 2/3 1, Phase 2 2) 2002: 25 trials (Observational 3, Not applicable 8, Phase 4 3, Phase 3 6, Phase 2 3, Phase 1/2 1, Phase 1 1) 2003: 41 trials (Observational 7, Not applicable 5, Phase 4 17, Phase 3 6, Phase 2/3 1, Phase 2 2, Phase 1 3) 2004: 49 trials (Observational 2, Not applicable 8, Phase 4 13, Phase 3 13, Phase 2/3 2, Phase 2 9, Phase 1/2 1, Phase 1 1) 2005: 56 trials (Observational 9, Not applicable 7, Phase 4 14, Phase 3 13, Phase 2 9, Phase 1 4) 2006: 71 trials (Observational 7, Not applicable 12, Phase 4 23, Phase 3 14, Phase 2 7, Phase 1/2 2, Phase 1 6) 2007: 59 trials (Observational 11, Not applicable 18, Phase 4 9, Phase 3 5, Phase 2/3 1, Phase 2 9, Phase 1/2 2, Phase 1 4) 2008: 45 trials (Observational 7, Not applicable 9, Phase 4 13, Phase 3 7, Phase 2 5, Phase 1 4) 2009: 56 trials (Observational 8, Not applicable 20, Phase 4 14, Phase 3 3, Phase 2 4, Phase 1/2 1, Phase 1 6) 2010: 47 trials (Observational 9, Not applicable 15, Phase 4 10, Phase 3 4, Phase 2/3 1, Phase 2 4, Phase 1/2 1, Phase 1 3) 2011: 53 trials (Observational 8, Not applicable 20, Phase 4 10, Phase 3 2, Phase 2 6, Phase 1 7) 2012: 47 trials (Observational 6, Not applicable 26, Phase 4 6, Phase 2 6, Phase 1/2 1, Phase 1 2) 2013: 54 trials (Observational 8, Not applicable 27, Phase 4 4, Phase 3 4, Phase 2 4, Phase 1/2 1, Phase 1 6) 2014: 64 trials (Observational 6, Not applicable 32, Phase 4 8, Phase 3 1, Phase 2/3 1, Phase 2 7, Phase 1/2 1, Phase 1 8) 2015: 65 trials (Observational 6, Not applicable 32, Phase 4 6, Phase 3 4, Phase 2/3 1, Phase 2 7, Phase 1 9) 2016: 65 trials (Observational 9, Not applicable 41, Phase 4 5, Phase 3 3, Phase 2 2, Phase 1/2 1, Phase 1 4) 2017: 48 trials (Observational 9, Not applicable 28, Phase 3 3, Phase 2/3 1, Phase 2 5, Phase 1 2) 2018: 59 trials (Observational 10, Not applicable 37, Phase 4 3, Phase 3 1, Phase 2 4, Phase 1/2 2, Phase 1 2) 2019: 86 trials (Observational 13, Not applicable 54, Phase 4 8, Phase 3 2, Phase 2/3 1, Phase 2 5, Phase 1/2 3) 2020: 60 trials (Observational 7, Not applicable 38, Phase 4 2, Phase 3 2, Phase 2 7, Phase 1/2 1, Phase 1 3) 2021: 76 trials (Observational 10, Not applicable 54, Phase 4 1, Phase 3 1, Phase 2/3 1, Phase 2 2, Phase 1 7) 2022: 71 trials (Observational 8, Not applicable 46, Phase 4 4, Phase 3 2, Phase 2 5, Phase 1/2 3, Phase 1 3) 2023: 83 trials (Observational 11, Not applicable 59, Phase 4 7, Phase 3 3, Phase 2 2, Phase 1 1) 2024: 78 trials (Observational 18, Not applicable 48, Phase 4 5, Phase 3 2, Phase 2/3 1, Phase 2 2, Phase 1 2) 2025: 66 trials (Observational 15, Not applicable 40, Phase 4 5, Phase 3 2, Phase 2 3, Phase 1 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 66
2025 66
2024 78
2023 83
2022 71
2021 76
2020 60
2019 86
2018 59
2017 48

Forecast of the full-year count, planned starts included, not rows of this table: about 81 trials starting in 2026 and about 70 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 151 trials still running at the 2026-10-09 snapshot; registered median of 31 months across 998 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Psychotic Disorders trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 92
Phase 1/2 22
Phase 2 128
Phase 2/3 16
Phase 3 125
Phase 4 213
Not applicable 755
Observational 225

How many Psychotic Disorders trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 54
Recruiting 177
Enrolling by invitation 10
Active, not recruiting 36
Completed 988

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Psychotic Disorders trials? (4)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
VA Office of Research and Development 40
National Institute of Mental Health (NIMH) 19
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 18
US Department of Veterans Affairs 17

Which drugs are being tested for Psychotic Disorders? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Aripiprazole 49
Cannabidiol 9
Brexpiprazole 9

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
IR Risperidone 82
Treatment As Usual 53
IM olanzapine 46
IR (Immediate-Release) quetiapine fumarate (drug) 36
only ziprasidone 31

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Psychotic Disorders trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Schizophrenia 336 22
Admission for Cardiovascular Disease 253 1
Suicidal ideation 155 21
Psychiatric Hospitalization/illness 130 1
first relapse often hospitalization 109 1

Which publications cover Psychotic Disorders? (1,551)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages