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Condition (MeSH)

Seizures

ClinicalTrials.gov lists 842 trials for Seizures or a narrower condition beneath it. National Institute of Neurological Disorders and Stroke (NINDS) has the most among industry and government lead sponsors, with 32.

MeSH D012640 Nervous System Diseases C10 C23
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Phase 1 Phase 1 39 Phase 1/2 Phase 1/2 15 Phase 2 Phase 2 101 Phase 2/3 Phase 2/3 22 Phase 3 Phase 3 160 Phase 4 Phase 4 67 Not applicable Not applicable 188 Observational Observational 249 Phase 1 Phase 1 39 Phase 1/2 Phase 1/2 15 Phase 2 Phase 2 101 Phase 2/3 Phase 2/3 22 Phase 3 Phase 3 160 Phase 4 Phase 4 67 Not applicable Not applicable 188 Observational Observational 249

Trials per phase

1 more section with rows

713 of the 842 trials are tagged with Seizures itself; the rest are tagged with a narrower condition beneath it.

Get the Seizures report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Seizures trials start? (36)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 3 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 51

1991: 2 trials (Observational 1, Phase 3 1) 1992: 3 trials (Observational 1, Not applicable 1, Phase 3 1) 1993: 4 trials (Observational 1, Phase 3 2, Phase 2 1) 1994: 4 trials (Observational 1, Phase 3 3) 1995: 2 trials (Phase 3 2) 1996: 1 trials (Observational 1) 1997: 5 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 3 1) 1998: 3 trials (Observational 1, Phase 3 2) 1999: 2 trials (Observational 1, Phase 3 1) 2000: 8 trials (Observational 1, Not applicable 1, Phase 4 1, Phase 3 1, Phase 2 4) 2001: 6 trials (Observational 1, Not applicable 1, Phase 3 3, Phase 2 1) 2002: 9 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 3 4, Phase 2 1) 2003: 8 trials (Observational 3, Phase 4 2, Phase 3 1, Phase 2 2) 2004: 17 trials (Observational 2, Not applicable 5, Phase 4 1, Phase 3 6, Phase 2 1, Phase 1 2) 2005: 26 trials (Observational 6, Not applicable 3, Phase 4 4, Phase 3 8, Phase 2 2, Phase 1 3) 2006: 31 trials (Observational 6, Not applicable 4, Phase 4 3, Phase 3 12, Phase 2 4, Phase 1 2) 2007: 26 trials (Observational 3, Not applicable 4, Phase 4 3, Phase 3 10, Phase 2 4, Phase 1/2 1, Phase 1 1) 2008: 25 trials (Observational 3, Phase 4 3, Phase 3 10, Phase 2/3 3, Phase 2 5, Phase 1/2 1) 2009: 32 trials (Observational 5, Not applicable 7, Phase 4 2, Phase 3 7, Phase 2/3 1, Phase 2 8, Phase 1 2) 2010: 33 trials (Observational 6, Not applicable 5, Phase 4 6, Phase 3 8, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 4) 2011: 29 trials (Observational 13, Not applicable 3, Phase 4 2, Phase 3 5, Phase 2 3, Phase 1/2 1, Phase 1 2) 2012: 19 trials (Observational 6, Not applicable 5, Phase 4 1, Phase 3 4, Phase 2/3 1, Phase 2 2) 2013: 32 trials (Observational 12, Not applicable 4, Phase 4 6, Phase 3 5, Phase 2/3 1, Phase 2 1, Phase 1/2 2, Phase 1 1) 2014: 24 trials (Observational 8, Not applicable 5, Phase 4 1, Phase 3 3, Phase 2 4, Phase 1/2 1, Phase 1 2) 2015: 33 trials (Observational 9, Not applicable 8, Phase 4 2, Phase 3 4, Phase 2/3 1, Phase 2 5, Phase 1/2 2, Phase 1 2) 2016: 39 trials (Observational 17, Not applicable 7, Phase 4 2, Phase 3 8, Phase 2/3 2, Phase 2 2, Phase 1 1) 2017: 43 trials (Observational 14, Not applicable 13, Phase 4 4, Phase 3 7, Phase 2/3 2, Phase 2 3) 2018: 46 trials (Observational 17, Not applicable 12, Phase 3 3, Phase 2 13, Phase 1/2 1) 2019: 31 trials (Observational 11, Not applicable 7, Phase 4 5, Phase 3 3, Phase 2 3, Phase 1 2) 2020: 37 trials (Observational 14, Not applicable 13, Phase 3 3, Phase 2/3 1, Phase 2 3, Phase 1/2 2, Phase 1 1) 2021: 41 trials (Observational 15, Not applicable 14, Phase 4 1, Phase 3 4, Phase 2 5, Phase 1 2) 2022: 39 trials (Observational 14, Not applicable 10, Phase 4 1, Phase 3 8, Phase 2/3 1, Phase 2 4, Phase 1 1) 2023: 39 trials (Observational 16, Not applicable 10, Phase 4 4, Phase 3 3, Phase 2/3 2, Phase 2 3, Phase 1 1) 2024: 51 trials (Observational 12, Not applicable 21, Phase 4 4, Phase 3 4, Phase 2/3 4, Phase 2 4, Phase 1/2 1, Phase 1 1) 2025: 50 trials (Observational 13, Not applicable 15, Phase 4 4, Phase 3 7, Phase 2/3 2, Phase 2 4, Phase 1 5)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 27
2025 50
2024 51
2023 39
2022 39
2021 41
2020 37
2019 31
2018 46
2017 43

Forecast of the full-year count, planned starts included, not rows of this table: about 36 trials starting in 2026 and about 45 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 71 trials still running at the 2026-10-09 snapshot; registered median of 28 months across 510 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Seizures trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 39
Phase 1/2 15
Phase 2 101
Phase 2/3 22
Phase 3 160
Phase 4 67
Not applicable 188
Observational 249
Expanded access 1

How many Seizures trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 26
Recruiting 105
Enrolling by invitation 7
Active, not recruiting 28
Available 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Seizures trials? (11)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Institute of Neurological Disorders and Stroke (NINDS) 32
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 19
Eisai Inc. 16
SK Life Science, Inc. 15
GlaxoSmithKline 14

Which drugs are being tested for Seizures? (8)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Perampanel 26
Cannabidiol 11
Pregabalin 10
Phenytoin 10
PMI-150 (intranasal ketamine) 10

Interventions as named in the registry (7)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Levetiracetam XR 66
Topiramate IR 25
Lacosamide (LCM) syrup 19
D. Midazolam 11
Oxcarbazepine XR 11

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Seizures trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Convulsion 297 30
Seizure 200 29
Pneumonia 163 46
Depressed level of consciousness 132 4
Status epilepticus 129 43

Which publications cover Seizures? (1,355)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (4)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages