Condition (MeSH)
Tangier Disease
ClinicalTrials.gov lists 5 trials for Tangier Disease or a narrower condition beneath it. National Heart, Lung, and Blood Institute (NHLBI) has the most among industry and government lead sponsors, with 1.
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Trials per phase
5 of the 5 trials are tagged with Tangier Disease itself; the rest are tagged with a narrower condition beneath it.
When did Tangier Disease trials start? (2)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
| Year | Trials started |
|---|---|
| 2012 | 1 |
| 2011 | 3 |
No forecast is made for this condition: it averages 0.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 5 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Tangier Disease trials in? (3)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 3 | 3 |
| Not applicable | 1 |
| Observational | 1 |
How many Tangier Disease trials are recruiting? (2)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Completed | 4 |
| Terminated | 1 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Tangier Disease trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | 1 |
Which publications cover Tangier Disease? (7)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| ABCA1(Alabama): a novel variant associated with HDL deficiency and premature coronary artery disease. | Atherosclerosis | 2002 | Yes |
| Subpopulations of high density lipoproteins in homozygous and heterozygous Tangier disease. | Atherosclerosis | 2001 | Yes |
| The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. | Nature genetics | 1999 | Yes |
| Familial hypoalphalipoproteinemia in premature coronary artery disease. | Arteriosclerosis and thrombosis : a journal of vascular biology | 1993 | Yes |
| Genetic high density lipoprotein deficiency states and atherosclerosis. | Advances in experimental medicine and biology | 1986 | Yes |
Showing 5 of 7 publications.
Prevalence (6)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Tangier disease | Cases families | Worldwide | Not stated | Unspecified | |
| Tangier disease | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Unspecified |
| Tangier disease | Cases families | Worldwide | Not stated | Exact | |
| Tangier disease | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Exact |
| Tangier disease | Cases families | Worldwide | Not stated | Exact |
Showing 5 of 6 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Tangier disease | 31150 | Exact | Orphadata Science knowledge files, Product 1 |
| Tangier disease | 31150 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials and sub-conditions in mesh.
Not computed for conditions with fewer than 10 trials: drugs tested.