Condition (MeSH)
Trismus
ClinicalTrials.gov lists 105 trials for Trismus or a narrower condition beneath it.
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Trials per phase (log scale)
105 of the 105 trials are tagged with Trismus itself; the rest are tagged with a narrower condition beneath it.
When did Trismus trials start? (19)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 14
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 8 |
| 2025 | 9 |
| 2024 | 14 |
| 2023 | 9 |
| 2022 | 5 |
| 2021 | 7 |
| 2020 | 4 |
| 2019 | 9 |
| 2018 | 11 |
| 2017 | 6 |
Showing 10 of 19 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 10 trials starting in 2026 and about 10 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 26 months from start to primary completion across 9 trials still running at the 2026-10-09 snapshot; registered median of 9 months across 63 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Trismus trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 4 |
| Phase 2/3 | 1 |
| Phase 3 | 2 |
| Phase 4 | 16 |
| Not applicable | 72 |
| Observational | 8 |
How many Trismus trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 3 |
| Recruiting | 12 |
| Active, not recruiting | 5 |
| Completed | 61 |
| Terminated | 1 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which drugs are being tested for Trismus? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Platelet Rich Fibrin | 4 |
| A- PRF | 3 |
| arveles | 2 |
| Serratiopeptidase | 2 |
| : Arnica montana | 2 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Dexamethasone/Dexamethasone acetate | 8 |
| Control (placebo) group | 3 |
| Concentrated Growth Factor (CGF) | 2 |
| Physiotherapy | 2 |
| Triamcinolone Acetonide alone | 2 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Trismus trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| disease recurrence resulting in death | 3 | 1 |
| dehydration | 2 | 1 |
| esophageal stenosis | 2 | 1 |
| pneumonia | 2 | 1 |
| Ankle fracture | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Trismus? (181)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Efficiency of different treatment modalities on radiation induced trismus for maxillofacial cases: a parallel randomized clinical trial. | BMC oral health | 2025 | Yes |
| Preventing radiation-induced dysphagia and trismus in head and neck cancer-A randomized controlled trial. | Head & neck | 2025 | Yes |
| Evaluation of the effect of manual lymphatic drainage method on edema, pain and trismus after impacted bilateral mandibular third molar surgery: a randomized clinical trial. | BMC oral health | 2025 | Yes |
| Comparison of the effects of submucosal hyaluronidase and dexamethasone on postoperative edema, pain, trismus, and infection following impacted third molar surgery. | BMC oral health | 2024 | Yes |
| Reduced mouth opening in patients with head and neck cancer treated with radiation therapy: an analysis of the Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (OraRad). | Oral surgery, oral medicine, oral pathology and oral radiology | 2024 | Yes |
Showing 5 of 181 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, prevalence, rare-disease identity, and sub-conditions in mesh.