Condition (MeSH)
von Willebrand Diseases
ClinicalTrials.gov lists 102 trials for von Willebrand Diseases or a narrower condition beneath it. Takeda has the most among industry and government lead sponsors, with 8.
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Trials per phase (log scale)
1 more section with rows
95 of the 102 trials are tagged with von Willebrand Diseases itself; the rest are tagged with a narrower condition beneath it.
When did von Willebrand Diseases trials start? (25)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 13
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 5 |
| 2025 | 9 |
| 2024 | 6 |
| 2023 | 7 |
| 2022 | 3 |
| 2021 | 6 |
| 2020 | 7 |
| 2019 | 13 |
| 2018 | 4 |
| 2017 | 4 |
Showing 10 of 25 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 7 trials starting in 2026 and about 8 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 11 trials still running at the 2026-10-09 snapshot; registered median of 32 months across 54 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are von Willebrand Diseases trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 4 |
| Phase 1/2 | 2 |
| Phase 2 | 9 |
| Phase 2/3 | 1 |
| Phase 3 | 19 |
| Phase 4 | 4 |
| Not applicable | 8 |
| Observational | 54 |
| Expanded access | 1 |
How many von Willebrand Diseases trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 25 |
| Active, not recruiting | 4 |
| Available | 1 |
| Completed | 52 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most von Willebrand Diseases trials? (7)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Takeda | 8 |
| CSL Behring | 7 |
| Baxalta now part of Shire | 5 |
| Octapharma | 5 |
| American Thrombosis and Hemostasis Network | 3 |
Showing 5 of 7 sponsors.
Which drugs are being tested for von Willebrand Diseases? (6)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Vonicog Alfa | 4 |
| VGA039 | 2 |
| Wilate | 2 |
| Emicizumab | 2 |
| Neumega (Oprelvekin, Interleukin 11, IL-11) | 2 |
Showing 5 of 6 drugs.
Interventions as named in the registry (9)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| acid tranexamic | 5 |
| Recombinant Von Willebrand factor | 4 |
| Optivate | 3 |
| Biostate | 3 |
| Von Willebrand Factor | 3 |
Showing 5 of 9 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do von Willebrand Diseases trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Anaemia | 2 | 2 |
| Pneumonia | 2 | 2 |
| Abortion spontaneous | 1 | 1 |
| Bacteraemia | 1 | 1 |
| Chest discomfort | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover von Willebrand Diseases? (227)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| von Willebrand factor/factor VIII concentrate (Wilate) prophylaxis in children and adults with von Willebrand disease. | Blood advances | 2024 | Yes |
| Key Drivers of Coagulation Factor Use in Von Willebrand Disease During Hospitalization: An Overview of the French BERHLINGO Cohort. | Clinical drug investigation | 2024 | Yes |
| Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance. | Blood advances | 2023 | Yes |
| An evaluation of von Willebrand factor (recombinant) therapy for adult patients living with severe type 3 von Willebrand disease. | Expert review of hematology | 2023 | Yes |
| Recombinant von Willebrand factor and tranexamic acid for heavy menstrual bleeding in patients with mild and moderate von Willebrand disease in the USA (VWDMin): a phase 3, open-label, randomised, crossover trial. | The Lancet. Haematology | 2023 | Yes |
Showing 5 of 227 publications.
Prevalence (2)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Von Willebrand disease | Point prevalence | 1-5 / 10 000 | Worldwide | Not stated | Exact |
| Von Willebrand disease | Point prevalence | 1-5 / 10 000 | Worldwide | Not stated | Exact |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Von Willebrand disease | 903 | Exact | Orphadata Science knowledge files, Product 1 |
| Von Willebrand disease | 903 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Sub-conditions in MeSH (3)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.