Condition (MeSH)
Pyruvate Dehydrogenase Complex Deficiency Disease
ClinicalTrials.gov lists 9 trials for Pyruvate Dehydrogenase Complex Deficiency Disease or a narrower condition beneath it. Saol Therapeutics Inc has the most among industry and government lead sponsors, with 2.
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Trials per phase
9 of the 9 trials are tagged with Pyruvate Dehydrogenase Complex Deficiency Disease itself; the rest are tagged with a narrower condition beneath it.
When did Pyruvate Dehydrogenase Complex Deficiency Disease trials start? (6)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 3
- Observational
Top of scale: 2
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2025 | 1 |
| 2024 | 1 |
| 2020 | 2 |
| 2018 | 2 |
| 2015 | 1 |
| 2010 | 1 |
No forecast is made for this condition: it averages 0.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Pyruvate Dehydrogenase Complex Deficiency Disease trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 3 | 1 |
| Observational | 4 |
| Expanded access | 1 |
How many Pyruvate Dehydrogenase Complex Deficiency Disease trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 4 |
| Active, not recruiting | 1 |
| Available | 1 |
| Completed | 1 |
| Unknown status | 2 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Pyruvate Dehydrogenase Complex Deficiency Disease trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Saol Therapeutics Inc | 2 |
Which publications cover Pyruvate Dehydrogenase Complex Deficiency Disease? (18)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Lethal neonatal case and review of primary short-chain enoyl-CoA hydratase (SCEH) deficiency associated with secondary lymphocyte pyruvate dehydrogenase complex (PDC) deficiency. | Molecular genetics and metabolism | 2017 | Yes |
| Enzymatic testing sensitivity, variability and practical diagnostic algorithm for pyruvate dehydrogenase complex (PDC) deficiency. | Molecular genetics and metabolism | 2017 | Yes |
| The spectrum of pyruvate oxidation defects in the diagnosis of mitochondrial disorders. | Journal of inherited metabolic disease | 2015 | Yes |
| Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis. | Science translational medicine | 2013 | Yes |
| The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients. | Molecular genetics and metabolism | 2012 | Yes |
Showing 5 of 18 publications.
Prevalence (4)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Pyruvate dehydrogenase deficiency | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| Pyruvate dehydrogenase deficiency | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| Pyruvate dehydrogenase deficiency | Point prevalence | <1 / 1 000 000 | Europe | Not stated | Exact |
| Pyruvate dehydrogenase deficiency | Point prevalence | <1 / 1 000 000 | Europe | Not stated | Exact |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Pyruvate dehydrogenase deficiency | 765 | Exact | Orphadata Science knowledge files, Product 1 |
| Pyruvate dehydrogenase deficiency | 765 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials and sub-conditions in mesh.
Not computed for conditions with fewer than 10 trials: drugs tested.