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Condition (MeSH)

Leukemia, Neutrophilic, Chronic

ClinicalTrials.gov lists 112 trials for Leukemia, Neutrophilic, Chronic or a narrower condition beneath it. National Cancer Institute (NCI) has the most among industry and government lead sponsors, with 7.

MeSH D015467 Hemic and Lymphatic Diseases C15 C23 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 20 Phase 1/2 Phase 1/2 10 Phase 2 Phase 2 25 Phase 3 Phase 3 13 Not applicable Not applicable 27 Observational Observational 16 Unknown Unknown 1 Phase 1 Phase 1 20 Phase 1/2 Phase 1/2 10 Phase 2 Phase 2 25 Phase 3 Phase 3 13 Not applicable Not applicable 27 Observational Observational 16 Unknown Unknown 1

Trials per phase (log scale)

112 of the 112 trials are tagged with Leukemia, Neutrophilic, Chronic itself; the rest are tagged with a narrower condition beneath it.

Get the Leukemia, Neutrophilic, Chronic report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Leukemia, Neutrophilic, Chronic trials start? (22)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 3
  • Not applicable
  • Observational
  • Unknown

Top of scale: 15

1993: 1 trials (Phase 2 1) 1996: 1 trials (Phase 2 1) 1998: 3 trials (Not applicable 1, Phase 3 1, Phase 1 1) 1999: 3 trials (Not applicable 2, Phase 3 1) 2000: 3 trials (Not applicable 1, Phase 2 1, Phase 1 1) 2001: 3 trials (Not applicable 1, Phase 2 1, Phase 1 1) 2002: 10 trials (Not applicable 4, Phase 3 1, Phase 2 1, Phase 1/2 2, Phase 1 2) 2003: 4 trials (Not applicable 2, Phase 1/2 1, Phase 1 1) 2004: 8 trials (Observational 1, Not applicable 3, Phase 3 1, Phase 2 2, Phase 1 1) 2005: 13 trials (Observational 1, Not applicable 2, Phase 3 1, Phase 2 3, Phase 1/2 3, Phase 1 3) 2006: 9 trials (Observational 1, Not applicable 2, Phase 3 1, Phase 2 4, Phase 1 1) 2007: 10 trials (Observational 2, Not applicable 1, Phase 3 1, Phase 2 3, Phase 1 3) 2008: 15 trials (Observational 5, Not applicable 1, Phase 3 4, Phase 2 3, Phase 1/2 1, Phase 1 1) 2009: 10 trials (Unknown 1, Observational 4, Not applicable 2, Phase 3 1, Phase 1/2 1, Phase 1 1) 2010: 7 trials (Observational 2, Not applicable 3, Phase 2 2) 2011: 4 trials (Phase 3 1, Phase 2 1, Phase 1 2) 2012: 1 trials (Not applicable 1) 2014: 1 trials (Phase 2 1) 2019: 1 trials (Phase 1/2 1) 2020: 1 trials (Phase 1 1) 2022: 1 trials (Phase 2 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 1
2022 1
2020 1
2019 1
2014 1
2012 1
2011 4
2010 7
2009 10
2008 15

Showing 10 of 22 earlier years.

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No forecast is made for this condition: it averages 0.4 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Leukemia, Neutrophilic, Chronic trials in? (7)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 20
Phase 1/2 10
Phase 2 25
Phase 3 13
Not applicable 27
Observational 16
Unknown 1

How many Leukemia, Neutrophilic, Chronic trials are recruiting? (6)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Recruiting 3
Active, not recruiting 4
Completed 70
Terminated 23
Withdrawn 9

Showing 5 of 6 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Leukemia, Neutrophilic, Chronic trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Cancer Institute (NCI) 7
European Organisation for Research and Treatment of Cancer - EORTC 4

Which drugs are being tested for Leukemia, Neutrophilic, Chronic? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Cytoxan 18
Busulfan 17

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
SQ Fludarabine 18
Peripheral blood stem cell transplantation 16
IR Tacrolimus 14
HD- Methotrexate (MTX) 14
Thymoglobulin [Anti-Thymocyte Globulin (Rabbit)] 13

Showing 5 of 13 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Leukemia, Neutrophilic, Chronic trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Death 180 5
Infection 36 5
Graft versus host disease (GVHD) 34 1
Alveolar hemorrhage 20 1
Hypoxia 20 4

Showing 5 of 10 adverse events.

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Which publications cover Leukemia, Neutrophilic, Chronic? (1)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2020 Yes

Prevalence (3)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Chronic neutrophilic leukemia Annual incidence <1 / 1 000 000 Europe Not stated Unspecified
Chronic neutrophilic leukemia Annual incidence <1 / 1 000 000 Europe Not stated Exact
Chronic neutrophilic leukemia Annual incidence <1 / 1 000 000 Europe Not stated Exact

Rare-disease identity (2)

Shown in this order: exact, broader, narrower, other.

Rare-disease identity
Orphanet disease ORPHA code Relation Source
Chronic neutrophilic leukemia 86829 Exact Orphadata Science knowledge files, Product 1
Chronic neutrophilic leukemia 86829 Exact Orphanet Rare Disease Ontology (ORDO)

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: sub-conditions in mesh.

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