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Condition (MeSH)

Blood Loss, Surgical

ClinicalTrials.gov lists 212 trials for Blood Loss, Surgical or a narrower condition beneath it. HemoSonics LLC has the most among industry and government lead sponsors, with 6.

MeSH D016063 Pathological Conditions, Signs and Symptoms C23
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Phase 1 Phase 1 9 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 11 Phase 2/3 Phase 2/3 5 Phase 3 Phase 3 31 Phase 4 Phase 4 40 Not applicable Not applicable 70 Observational Observational 44 Phase 1 Phase 1 9 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 11 Phase 2/3 Phase 2/3 5 Phase 3 Phase 3 31 Phase 4 Phase 4 40 Not applicable Not applicable 70 Observational Observational 44

Trials per phase (log scale)

212 of the 212 trials are tagged with Blood Loss, Surgical itself; the rest are tagged with a narrower condition beneath it.

Get the Blood Loss, Surgical report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Blood Loss, Surgical trials start? (23)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 17

2004: 2 trials (Observational 2) 2005: 8 trials (Observational 2, Not applicable 1, Phase 3 4, Phase 2 1) 2006: 3 trials (Phase 4 1, Phase 3 2) 2007: 3 trials (Not applicable 1, Phase 4 1, Phase 2 1) 2008: 5 trials (Not applicable 1, Phase 4 1, Phase 3 2, Phase 2 1) 2009: 6 trials (Observational 1, Not applicable 1, Phase 4 3, Phase 3 1) 2010: 6 trials (Observational 2, Not applicable 1, Phase 3 3) 2011: 4 trials (Observational 1, Not applicable 2, Phase 4 1) 2012: 6 trials (Not applicable 1, Phase 4 1, Phase 3 2, Phase 2/3 2) 2013: 6 trials (Observational 1, Phase 4 2, Phase 3 1, Phase 2/3 1, Phase 2 1) 2014: 3 trials (Not applicable 1, Phase 4 1, Phase 1 1) 2015: 11 trials (Observational 2, Not applicable 5, Phase 4 2, Phase 3 1, Phase 2 1) 2016: 12 trials (Observational 2, Not applicable 4, Phase 4 5, Phase 1 1) 2017: 15 trials (Observational 3, Not applicable 4, Phase 4 5, Phase 3 1, Phase 2 2) 2018: 7 trials (Observational 3, Not applicable 2, Phase 4 1, Phase 3 1) 2019: 17 trials (Observational 4, Not applicable 6, Phase 4 3, Phase 3 3, Phase 2/3 1) 2020: 15 trials (Observational 5, Not applicable 7, Phase 3 1, Phase 2 1, Phase 1/2 1) 2021: 13 trials (Observational 3, Not applicable 4, Phase 4 2, Phase 3 3, Phase 1 1) 2022: 17 trials (Observational 3, Not applicable 8, Phase 4 4, Phase 1/2 1, Phase 1 1) 2023: 13 trials (Observational 3, Not applicable 7, Phase 4 2, Phase 2 1) 2024: 13 trials (Observational 1, Not applicable 6, Phase 4 2, Phase 3 3, Phase 2/3 1) 2025: 11 trials (Observational 2, Not applicable 4, Phase 4 2, Phase 3 1, Phase 2 1, Phase 1 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 14
2025 11
2024 13
2023 13
2022 17
2021 13
2020 15
2019 17
2018 7
2017 15

Forecast of the full-year count, planned starts included, not rows of this table: about 15 trials starting in 2026 and about 13 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 35 months from start to primary completion across 16 trials still running at the 2026-10-09 snapshot; registered median of 16 months across 131 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Blood Loss, Surgical trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 9
Phase 1/2 2
Phase 2 11
Phase 2/3 5
Phase 3 31
Phase 4 40
Not applicable 70
Observational 44

How many Blood Loss, Surgical trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 11
Recruiting 20
Enrolling by invitation 1
Active, not recruiting 4
Completed 117

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Blood Loss, Surgical trials? (7)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
HemoSonics LLC 6
Bayer 4
CytoSorbents, Inc 3
Egymedicalpedia 3
GATT Technologies BV 3

Which drugs are being tested for Blood Loss, Surgical? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
MisoprostoL 6
Trasylol (Aprotinin, BAYA0128) 4
DEXMEDETOMIDINE 3
Fresh Frozen Plasma 3

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
acid tranexamic 35
IM Oxytocin 5
carbetocin 100 µg 4
Tranexamic Acid Injectable Product 3
Epinephrin 3

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Blood Loss, Surgical trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Renal Failure 39 1
Post procedural bile leak 17 1
Prolonged mechanical ventilation 12 1
Re-operations 11 1
Intra abdominal fluid collection 9 1

Which publications cover Blood Loss, Surgical? (1,914)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Early CABG with intraoperative hemoadsorption in patients on ticagrelor: Real-world data from the international Safe and Timely Antithrombotic Removal (STAR) registry. Cardiovascular revascularization medicine : including molecular interventions 2026 Yes
Hypovolaemic phlebotomy in patients undergoing hepatic resection at higher risk of blood loss (PRICE-2): a randomised controlled trial. The lancet. Gastroenterology & hepatology 2025 Yes
Is Tranexamic Acid Associated With a Reduced Need for Hypotensive Anesthesia During Orthognathic Surgery? Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2025 Yes
Effect of hot saline irrigation on the operative field during endoscopic sinus surgery: a randomized controlled trial. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2025 Yes
Comparative efficacy of tranexamic acid versus placebo on hemostatic outcomes after the surgical debridement of burn patients: A randomized controlled clinical trial. Burns : journal of the International Society for Burn Injuries 2025 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

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