Condition (MeSH)
Head Injuries, Closed
ClinicalTrials.gov lists 710 trials for Head Injuries, Closed or a narrower condition beneath it. VA Office of Research and Development has the most among industry and government lead sponsors, with 26.
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Trials per phase (log scale)
33 of the 710 trials are tagged with Head Injuries, Closed itself; the rest are tagged with a narrower condition beneath it.
When did Head Injuries, Closed trials start? (25)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 72
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 40 |
| 2025 | 43 |
| 2024 | 49 |
| 2023 | 53 |
| 2022 | 47 |
| 2021 | 72 |
| 2020 | 33 |
| 2019 | 45 |
| 2018 | 47 |
| 2017 | 47 |
Showing 10 of 25 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 48 trials starting in 2026 and about 41 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 93 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 425 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Head Injuries, Closed trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 26 |
| Phase 1/2 | 7 |
| Phase 2 | 38 |
| Phase 2/3 | 4 |
| Phase 3 | 10 |
| Phase 4 | 6 |
| Not applicable | 434 |
| Observational | 185 |
How many Head Injuries, Closed trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 30 |
| Recruiting | 109 |
| Enrolling by invitation | 15 |
| Active, not recruiting | 25 |
| Completed | 351 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Head Injuries, Closed trials? (2)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| VA Office of Research and Development | 26 |
| BrainScope Company, Inc. | 7 |
Which drugs are being tested for Head Injuries, Closed? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| SILDENAFIL | 4 |
| Creatine | 3 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Hyperbaric Oxygen | 10 |
| Aerobic exercise | 9 |
| somatropin AQ | 5 |
| Treatment As Usual | 5 |
| Exercise | 4 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Head Injuries, Closed trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Medical hospitalization | 5 | 1 |
| self-reported interpersonal violence | 3 | 1 |
| Inpatient Hospitalization | 2 | 1 |
| Muscle pain | 2 | 1 |
| Planned surgical procedure | 2 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Head Injuries, Closed? (92)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Low Incidence of Delayed Intracranial Hemorrhage in Geriatric Emergency Department Patients on Preinjury Anticoagulation Presenting with Blunt Head Trauma. | The Journal of emergency medicine | 2024 | Yes |
| Association of Acute Increase in Plasma Neurofilament Light with Repetitive Subconcussive Head Impacts: A Pilot Randomized Control Trial. | Journal of neurotrauma | 2019 | Yes |
| Cerebrolysin Reduces Astrogliosis and Axonal Injury and Enhances Neurogenesis in Rats After Closed Head Injury. | Neurorehabilitation and neural repair | 2019 | Yes |
| Implementation of a Clinical Decision Support System for Children With Minor Blunt Head Trauma Who Are at Nonnegligible Risk for Traumatic Brain Injuries. | Annals of emergency medicine | 2019 | Yes |
| Intracranial pressure monitoring in severe blunt head trauma: does the type of monitoring device matter? | Journal of neurosurgery | 2018 | Yes |
Showing 5 of 92 publications.
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.