Condition (MeSH)
Seasonal Affective Disorder
ClinicalTrials.gov lists 31 trials for Seasonal Affective Disorder or a narrower condition beneath it. GlaxoSmithKline has the most among industry and government lead sponsors, with 3.
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Trials per phase
31 of the 31 trials are tagged with Seasonal Affective Disorder itself; the rest are tagged with a narrower condition beneath it.
When did Seasonal Affective Disorder trials start? (20)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 4
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2025 | 1 |
| 2023 | 1 |
| 2021 | 1 |
| 2020 | 1 |
| 2018 | 2 |
| 2017 | 2 |
| 2013 | 2 |
| 2012 | 1 |
| 2011 | 1 |
| 2010 | 1 |
Showing 10 of 20 earlier years.
No forecast is made for this condition: it averages 0.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 31 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Seasonal Affective Disorder trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 2 |
| Phase 2/3 | 1 |
| Phase 3 | 2 |
| Phase 4 | 2 |
| Not applicable | 18 |
| Observational | 4 |
How many Seasonal Affective Disorder trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 1 |
| Completed | 26 |
| Withdrawn | 1 |
| Unknown status | 2 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Seasonal Affective Disorder trials? (2)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| GlaxoSmithKline | 3 |
| National Institute of Mental Health (NIMH) | 2 |
Which drugs are being tested for Seasonal Affective Disorder? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Calcium-vitamin D3 | 1 |
| Ramelteon | 1 |
| Calcium/Vitamin D | 1 |
Interventions as named in the registry (3)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| BupropionXL | 2 |
| Propranolol PO | 1 |
| Investigational Seasonal Affective Disorder (SAD) Drug | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Seasonal Affective Disorder trials report? (1)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Worsening depression leading to hospitalization | 1 | 1 |
Which publications cover Seasonal Affective Disorder? (69)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Summer and SERT: Effect of daily sunshine hours on <i>SLC6A4</i> promoter methylation in seasonal affective disorder. | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry | 2025 | Yes |
| Prospectively assessed summer mood status in major depression, recurrent with seasonal pattern: Evidence for SAD's construct validity. | Journal of affective disorders | 2024 | Yes |
| Personality Pathology in Winter Depression: Prevalence and Treatment Trajectories in Cognitive-Behavioral Therapy and Light Therapy. | Behavior therapy | 2023 | Yes |
| Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo. | Translational psychiatry | 2023 | Yes |
| Change in Seasonal Beliefs Mediates the Durability Advantage of Cognitive-Behavioral Therapy Over Light Therapy for Winter Depression. | Behavior therapy | 2023 | Yes |
Showing 5 of 69 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.