Condition (MeSH)
HELLP Syndrome
ClinicalTrials.gov lists 34 trials for HELLP Syndrome or a narrower condition beneath it.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase
34 of the 34 trials are tagged with HELLP Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did HELLP Syndrome trials start? (16)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 4 |
| 2024 | 2 |
| 2023 | 2 |
| 2021 | 3 |
| 2019 | 1 |
| 2018 | 1 |
| 2017 | 3 |
| 2016 | 5 |
| 2015 | 4 |
| 2014 | 2 |
Showing 10 of 16 earlier years.
No forecast is made for this condition: it averages 1.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 34 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are HELLP Syndrome trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
| Phase 2/3 | 1 |
| Phase 3 | 4 |
| Phase 4 | 4 |
| Not applicable | 4 |
| Observational | 19 |
How many HELLP Syndrome trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 4 |
| Recruiting | 4 |
| Completed | 17 |
| Terminated | 2 |
| Withdrawn | 1 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most HELLP Syndrome trials? (2)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Africa Clinical Research Network (ACRN) | 1 |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 1 |
Which drugs are being tested for HELLP Syndrome? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Eculizumab | 2 |
Interventions as named in the registry (14)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Dexamethasone/Dexamethasone acetate | 2 |
| Double distilled water | 1 |
| Bloodwork, baseline | 1 |
| Ibuprofen 2% | 1 |
| General Anesthesia | 1 |
Showing 5 of 14 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do HELLP Syndrome trials report? (3)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Inpatient readmission | 3 | 1 |
| Acute postpartum elevation of liver function tests | 1 | 1 |
| Neonatal death | 1 | 1 |
Which publications cover HELLP Syndrome? (29)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| HELLP Syndrome-Holistic Insight into Pathophysiology. | Medicina (Kaunas, Lithuania) | 2022 | Yes |
| Molecular Advances in Preeclampsia and HELLP Syndrome. | International journal of molecular sciences | 2022 | Yes |
| Prevalence of hypertensive disorders during pregnancy in France (2010-2018): The Nationwide CONCEPTION Study. | Journal of clinical hypertension (Greenwich, Conn.) | 2021 | Yes |
| Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. | BJOG : an international journal of obstetrics and gynaecology | 2020 | Yes |
| Blood pressure after PREeclampsia/HELLP by SELF monitoring (BP-PRESELF): rationale and design of a multicenter randomized controlled trial. | BMC women's health | 2020 | Yes |
Showing 5 of 29 publications.
Prevalence (3)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| HELLP syndrome | Point prevalence | Unknown | Worldwide | Not stated | Unspecified |
| HELLP syndrome | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| HELLP syndrome | Point prevalence | Unknown | Worldwide | Not stated | Exact |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| HELLP syndrome | 244242 | Exact | Orphadata Science knowledge files, Product 1 |
| HELLP syndrome | 244242 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.