Condition (MeSH)
Exfoliation Syndrome
ClinicalTrials.gov lists 72 trials for Exfoliation Syndrome or a narrower condition beneath it. Vastra Gotaland Region has the most among industry and government lead sponsors, with 3.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
72 of the 72 trials are tagged with Exfoliation Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Exfoliation Syndrome trials start? (25)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 7
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 5 |
| 2025 | 3 |
| 2024 | 3 |
| 2023 | 7 |
| 2022 | 3 |
| 2021 | 3 |
| 2020 | 6 |
| 2019 | 4 |
| 2018 | 3 |
| 2017 | 3 |
Showing 10 of 25 earlier years.
No forecast is made for this condition: it averages 4.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 7 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 37 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Exfoliation Syndrome trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1/2 | 1 |
| Phase 2 | 1 |
| Phase 2/3 | 1 |
| Phase 3 | 2 |
| Phase 4 | 4 |
| Not applicable | 25 |
| Observational | 38 |
How many Exfoliation Syndrome trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 4 |
| Recruiting | 12 |
| Enrolling by invitation | 3 |
| Active, not recruiting | 2 |
| Completed | 32 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Exfoliation Syndrome trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Vastra Gotaland Region | 3 |
| Alcon Research | 1 |
| AqueSys, Inc. | 1 |
Interventions as named in the registry (15)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| travoprost 0.003% | 2 |
| Cataract surgery | 2 |
| Travoprost/timolol fixed combination (Travacom) | 1 |
| Topical Lidocaine | 1 |
| Dorzolamide/timolol Maleate Fixed Combination (COSOPT) | 1 |
Showing 5 of 15 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Exfoliation Syndrome trials report? (3)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Secondary glaucoma procedure with explant | 6 | 1 |
| Secondary glaucoma procedure | 2 | 1 |
| Explant | 1 | 1 |
Which publications cover Exfoliation Syndrome? (82)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Innovative approach to IOL-bag complex fixation with Siepser's scleral sliding knots in pseudoexfoliation syndrome. | Scientific reports | 2025 | Yes |
| The role of serum biomarkers in determining systemic inflammation and cardiovascular risk in pseudoexfoliation syndrome. | International ophthalmology | 2024 | Yes |
| Single nucleotide polymorphisms in LOXL1 as biomarkers for progression of exfoliation glaucoma in Sweden. | Acta ophthalmologica | 2023 | Yes |
| Evaluation of the corneal thickness and endothelial changes following uncomplicated phacoemulsification in diabetic and non-diabetic patients with pseudo-exfoliation syndrome by specular microscopy. | International ophthalmology | 2023 | Yes |
| Electrodiagnostic signs of carpal tunnel syndrome in ocular pseudoexfoliation syndrome. | International ophthalmology | 2022 | Yes |
Showing 5 of 82 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.