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Condition (MeSH)

Capillary Leak Syndrome

ClinicalTrials.gov lists 5 trials for Capillary Leak Syndrome or a narrower condition beneath it.

MeSH D019559 Cardiovascular Diseases C14 Listed by Orphanet as a rare disease
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Trials started per year Trials started per year 5 Trials by phase Trials by phase 1 Trials by recruitment status Trials by recruitment status 2 Lead sponsors Lead sponsors 2 Publications Publications 20 Prevalence Prevalence 6 Rare-disease identity Rare-disease identity 2 Trials started per year Trials started per year 5 Trials by phase Trials by phase 1 Trials by recruitment status Trials by recruitment status 2 Lead sponsors Lead sponsors 2 Publications Publications 20 Prevalence Prevalence 6 Rare-disease identity Rare-disease identity 2

Rows recorded per section (log scale)

2 sections measured, none recorded · 1 not measured yet · 1 not computed

5 of the 5 trials are tagged with Capillary Leak Syndrome itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Capillary Leak Syndrome trials start? (5)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Observational

Top of scale: 1

2009: 1 trials (Observational 1) 2015: 1 trials (Observational 1) 2016: 1 trials (Observational 1) 2018: 1 trials (Observational 1) 2019: 1 trials (Observational 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2019 1
2018 1
2016 1
2015 1
2009 1

No forecast is made for this condition: it averages 0.0 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: none of the 5 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Capillary Leak Syndrome trials in? (1)

Shown in this order: phase order.

Trials by phase
Phase Trials
Observational 5

How many Capillary Leak Syndrome trials are recruiting? (2)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Completed 4
Terminated 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Capillary Leak Syndrome trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
AstraZeneca 1
National Institute of Allergy and Infectious Diseases (NIAID) 1

Which publications cover Capillary Leak Syndrome? (20)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Fatal capillary leak syndrome in a child with acute lymphoblastic leukemia treated with moxetumomab pasudotox for pre-transplant minimal residual disease reduction. Pediatric blood & cancer 2021 Yes
Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers. Critical care (London, England) 2020 Yes
Characterizing drug-induced capillary leak syndromes using the World Health Organization VigiBase. The Journal of allergy and clinical immunology 2019 Yes
Interleukin-6 in sepsis and capillary leakage syndrome. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2012 Yes
The role of the endothelium in the short-term complications of hematopoietic SCT. Bone marrow transplantation 2011 Yes

Showing 5 of 20 publications.

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Prevalence (6)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Systemic capillary leak syndrome Point prevalence <1 / 1 000 000 Worldwide Not stated Exact
Systemic capillary leak syndrome Point prevalence <1 / 1 000 000 Worldwide Not stated Exact
Systemic capillary leak syndrome Point prevalence <1 / 1 000 000 Worldwide Not stated Unspecified
Systemic capillary leak syndrome Cases families Worldwide Not stated Unspecified
Systemic capillary leak syndrome Cases families Worldwide Not stated Exact

Showing 5 of 6 prevalence observations.

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Rare-disease identity (2)

Shown in this order: exact, broader, narrower, other.

Rare-disease identity
Orphanet disease ORPHA code Relation Source
Systemic capillary leak syndrome 188 Exact Orphanet Rare Disease Ontology (ORDO)
Systemic capillary leak syndrome 188 Exact Orphadata Science knowledge files, Product 1

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: serious adverse events in this condition's trials and sub-conditions in mesh.

Not computed for conditions with fewer than 10 trials: drugs tested.

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