Condition (MeSH)
Genetic Predisposition to Disease
ClinicalTrials.gov lists 284 trials for Genetic Predisposition to Disease or a narrower condition beneath it. National Institute of Environmental Health Sciences (NIEHS) has the most among industry and government lead sponsors, with 7.
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Trials per phase (log scale)
237 of the 284 trials are tagged with Genetic Predisposition to Disease itself; the rest are tagged with a narrower condition beneath it.
When did Genetic Predisposition to Disease trials start? (33)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 28
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 20 |
| 2025 | 21 |
| 2024 | 24 |
| 2023 | 20 |
| 2022 | 18 |
| 2021 | 28 |
| 2020 | 18 |
| 2019 | 28 |
| 2018 | 20 |
| 2017 | 13 |
Showing 10 of 33 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 20 trials starting in 2026 and about 20 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 33 trials still running at the 2026-10-09 snapshot; registered median of 30 months across 117 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Genetic Predisposition to Disease trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 3 |
| Phase 3 | 2 |
| Phase 4 | 4 |
| Not applicable | 93 |
| Observational | 178 |
How many Genetic Predisposition to Disease trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 18 |
| Recruiting | 82 |
| Enrolling by invitation | 11 |
| Active, not recruiting | 20 |
| Completed | 100 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Genetic Predisposition to Disease trials? (2)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Institute of Environmental Health Sciences (NIEHS) | 7 |
| National Cancer Institute (NCI) | 4 |
Which drugs are being tested for Genetic Predisposition to Disease? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Sirolimus | 2 |
Interventions as named in the registry (14)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| BLOOD SAMPLE | 2 |
| Next Generation Sequencing (DNA and RNA) | 2 |
| Blood Sampling | 2 |
| Semaglutide or Tirzepatide | 1 |
| Metoprolol XL | 1 |
Showing 5 of 14 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Genetic Predisposition to Disease trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Other Unspecified Adverse Event | 405 | 1 |
| Other Unspecified Infection | 123 | 1 |
| Hospitalization | 99 | 1 |
| Upper Respiratory Infection | 97 | 1 |
| Gastroenteritis | 64 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Genetic Predisposition to Disease? (4,318)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| A multi-ancestry genome-wide association study identifies novel candidate loci in the RARB gene associated with hypertensive disorders of pregnancy. | HGG advances | 2025 | Yes |
| Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility. | BMC cancer | 2025 | Yes |
| The impact of rare genetic variants on Alzheimer disease. | Nature reviews. Neurology | 2025 | Yes |
| The Genetic Information and Family Testing (GIFT) study: trial design and protocol. | BMC cancer | 2025 | Yes |
| Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification. | Alzheimer's & dementia : the journal of the Alzheimer's Association | 2025 | Yes |
Showing 5 of 4,318 publications.
Sub-conditions in MeSH (2)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.