Condition (MeSH)
Hepatopulmonary Syndrome
ClinicalTrials.gov lists 15 trials for Hepatopulmonary Syndrome or a narrower condition beneath it.
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Trials per phase
15 of the 15 trials are tagged with Hepatopulmonary Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Hepatopulmonary Syndrome trials start? (12)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Not applicable
- Observational
Top of scale: 2
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2023 | 1 |
| 2022 | 1 |
| 2021 | 1 |
| 2019 | 1 |
| 2018 | 2 |
| 2017 | 1 |
| 2015 | 1 |
| 2014 | 2 |
| 2012 | 1 |
| 2011 | 1 |
Showing 10 of 12 earlier years.
No forecast is made for this condition: it averages 0.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Hepatopulmonary Syndrome trials in? (4)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 4 |
| Not applicable | 3 |
| Observational | 6 |
How many Hepatopulmonary Syndrome trials are recruiting? (4)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Enrolling by invitation | 1 |
| Completed | 3 |
| Terminated | 4 |
| Unknown status | 7 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which drugs are being tested for Hepatopulmonary Syndrome? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Pentoxifylline | 2 |
| Sorafenib | 1 |
| Norfloxacin | 1 |
| BOSENTAN | 1 |
Interventions as named in the registry (4)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Midodrine 2.5 mg tab | 1 |
| Letrozol (Femara, Novartis) | 1 |
| pentoxifylline and rifaximin | 1 |
| Proteomic sequencing | 1 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Hepatopulmonary Syndrome trials report? (8)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Liver transplant | 3 | 1 |
| Basal cell carcinoma | 2 | 1 |
| Encephalopathy | 2 | 1 |
| Diagnostic procedure | 1 | 1 |
| Hypoxia | 1 | 1 |
Showing 5 of 8 adverse events.
Which publications cover Hepatopulmonary Syndrome? (13)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Supine vs upright exercise in patients with hepatopulmonary syndrome and orthodeoxia: study protocol for a randomized controlled crossover trial. | Trials | 2021 | Yes |
| Biliary atresia: Indications and timing of liver transplantation and optimization of pretransplant care. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2017 | Yes |
| Inflammatory bowel diseases, chronic liver diseases and the lung. | The European respiratory journal | 2016 | Yes |
| Norfloxacin therapy for hepatopulmonary syndrome: a pilot randomized controlled trial. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association | 2010 | Yes |
| Pilot study of pentoxifylline in hepatopulmonary syndrome. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2008 | Yes |
Showing 5 of 13 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, prevalence, rare-disease identity, and sub-conditions in mesh.