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Condition (MeSH)

Protein C Deficiency

ClinicalTrials.gov lists 5 trials for Protein C Deficiency or a narrower condition beneath it. Baxalta now part of Shire has the most among industry and government lead sponsors, with 3.

MeSH D020151 Hemic and Lymphatic Diseases C15 C16 Listed by Orphanet as a rare disease
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Phase 2/3 Phase 2/3 1 Observational Observational 4 Phase 2/3 Phase 2/3 1 Observational Observational 4

Trials per phase

5 of the 5 trials are tagged with Protein C Deficiency itself; the rest are tagged with a narrower condition beneath it.

Get the Protein C Deficiency report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Protein C Deficiency trials start? (5)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 2/3
  • Observational

Top of scale: 1

2003: 1 trials (Phase 2/3 1) 2005: 1 trials (Observational 1) 2010: 1 trials (Observational 1) 2020: 1 trials (Observational 1) 2024: 1 trials (Observational 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2024 1
2020 1
2010 1
2005 1
2003 1

No forecast is made for this condition: it averages 0.2 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: none of the 5 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Protein C Deficiency trials in? (2)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 2/3 1
Observational 4

How many Protein C Deficiency trials are recruiting? (3)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Recruiting 1
Completed 3
Unknown status 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Protein C Deficiency trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Baxalta now part of Shire 3
Takeda 1

Which publications cover Protein C Deficiency? (15)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
A case of polycystic ovary syndrome with inevitable miscarriage and multi-site venous thrombosis caused by hereditary protein C deficiency. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2022 Yes
Protein C and protein S deficiency - practical diagnostic issues. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2013 Yes
Thrombotic risk in hereditary antithrombin III, protein C, or protein S deficiency. A cooperative, retrospective study. Gesellschaft fur Thrombose- und Hamostaseforschung (GTH) Study Group on Natural Inhibitors. Arteriosclerosis, thrombosis, and vascular biology 1996 Yes
Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet (London, England) 1993 Yes
Intracardiac thrombosis diagnosed by echocardiography in childhood: predisposing and etiological factors. International journal of cardiology 1993 Yes

Prevalence (2)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Severe hereditary thrombophilia due to congenital protein C deficiency Prevalence at birth 1-9 / 1 000 000 Worldwide Not stated Unspecified
Severe hereditary thrombophilia due to congenital protein C deficiency Point prevalence Unknown Worldwide Not stated Unspecified

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, rare-disease identity, and sub-conditions in mesh.

Not computed for conditions with fewer than 10 trials: drugs tested.

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