Condition (MeSH)
Postoperative Nausea and Vomiting
ClinicalTrials.gov lists 628 trials for Postoperative Nausea and Vomiting or a narrower condition beneath it. Acacia Pharma Ltd has the most among industry and government lead sponsors, with 10.
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Trials per phase (log scale)
1 more section with rows
628 of the 628 trials are tagged with Postoperative Nausea and Vomiting itself; the rest are tagged with a narrower condition beneath it.
When did Postoperative Nausea and Vomiting trials start? (25)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 55
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 45 |
| 2025 | 55 |
| 2024 | 39 |
| 2023 | 43 |
| 2022 | 46 |
| 2021 | 46 |
| 2020 | 36 |
| 2019 | 27 |
| 2018 | 42 |
| 2017 | 28 |
Showing 10 of 25 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 58 trials starting in 2026 and about 54 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 30 months from start to primary completion across 46 trials still running at the 2026-10-09 snapshot; registered median of 11 months across 423 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Postoperative Nausea and Vomiting trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 10 |
| Phase 1/2 | 6 |
| Phase 2 | 40 |
| Phase 2/3 | 12 |
| Phase 3 | 53 |
| Phase 4 | 141 |
| Not applicable | 272 |
| Observational | 93 |
| Expanded access | 1 |
How many Postoperative Nausea and Vomiting trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 32 |
| Recruiting | 46 |
| Enrolling by invitation | 4 |
| Active, not recruiting | 10 |
| Completed | 396 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Postoperative Nausea and Vomiting trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Acacia Pharma Ltd | 10 |
| GlaxoSmithKline | 5 |
| Merck Sharp & Dohme LLC | 5 |
Which drugs are being tested for Postoperative Nausea and Vomiting? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Aprepitant | 27 |
| DEXMEDETOMIDINE | 16 |
| GRANISETRON | 12 |
| PROPOFOL | 11 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Dexamethasone/Dexamethasone acetate | 83 |
| Ondansetron - Parts A + B | 62 |
| I.V. palonosetron | 24 |
| ramosetron 0.6 | 17 |
| Amisulpride Pill | 12 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Postoperative Nausea and Vomiting trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Drowsiness | 52 | 1 |
| Mortality - CDS Email Recommendations | 43 | 1 |
| Mortality - CDS Email + Real Time Recommendations | 40 | 1 |
| PONV | 14 | 1 |
| wound hemorrhage | 8 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Postoperative Nausea and Vomiting? (1,055)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Opioid-Sparing Anesthesia Versus Opioid-Free Anesthesia for the Prevention of Postoperative Nausea and Vomiting after Laparoscopic Bariatric Surgery: A Systematic Review and Network Meta-Analysis. | Anesthesia and analgesia | 2025 | Yes |
| The Effects of Acupressure on Preoperative Anxiety, Postoperative Pain, and Nausea and Vomiting in Otolaryngology Patients. | Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses | 2025 | Yes |
| Chewing Gum to Treat Postoperative Nausea and Vomiting in Female Patients: A Multicenter Randomized Trial. | Anesthesiology | 2025 | Yes |
| Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery: A Randomized Clinical Trial. | JAMA | 2025 | Yes |
| The effect of an aromatic solution applied after percutaneous nephrolithotomy on sore throat, thirst, and nausea-vomiting: A randomised controlled trial. | Complementary therapies in clinical practice | 2025 | Yes |
Showing 5 of 1,055 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.