Skip to content
Pharma Observatory a Scientist.com platform

Condition (MeSH)

Postoperative Nausea and Vomiting

ClinicalTrials.gov lists 628 trials for Postoperative Nausea and Vomiting or a narrower condition beneath it. Acacia Pharma Ltd has the most among industry and government lead sponsors, with 10.

MeSH D020250 Pathological Conditions, Signs and Symptoms C23
Email me this page as a PDF

Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Phase 1 Phase 1 10 Phase 1/2 Phase 1/2 6 Phase 2 Phase 2 40 Phase 2/3 Phase 2/3 12 Phase 3 Phase 3 53 Phase 4 Phase 4 141 Not applicable Not applicable 272 Observational Observational 93 Phase 1 Phase 1 10 Phase 1/2 Phase 1/2 6 Phase 2 Phase 2 40 Phase 2/3 Phase 2/3 12 Phase 3 Phase 3 53 Phase 4 Phase 4 141 Not applicable Not applicable 272 Observational Observational 93

Trials per phase (log scale)

1 more section with rows

628 of the 628 trials are tagged with Postoperative Nausea and Vomiting itself; the rest are tagged with a narrower condition beneath it.

Get the Postoperative Nausea and Vomiting report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Postoperative Nausea and Vomiting trials start? (25)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 55

2002: 1 trials (Phase 3 1) 2003: 1 trials (Phase 3 1) 2004: 3 trials (Phase 3 1, Phase 2 2) 2005: 8 trials (Not applicable 3, Phase 4 3, Phase 2 1, Phase 1 1) 2006: 5 trials (Not applicable 1, Phase 3 2, Phase 2 1, Phase 1/2 1) 2007: 11 trials (Observational 1, Not applicable 1, Phase 4 6, Phase 3 1, Phase 2 2) 2008: 20 trials (Observational 2, Not applicable 6, Phase 4 7, Phase 3 2, Phase 2/3 1, Phase 2 1, Phase 1/2 1) 2009: 22 trials (Not applicable 9, Phase 4 7, Phase 3 1, Phase 2 4, Phase 1 1) 2010: 15 trials (Observational 1, Not applicable 7, Phase 4 4, Phase 3 2, Phase 2 1) 2011: 20 trials (Observational 2, Not applicable 8, Phase 4 4, Phase 3 3, Phase 2/3 1, Phase 2 1, Phase 1 1) 2012: 18 trials (Observational 2, Not applicable 4, Phase 4 8, Phase 3 1, Phase 2 3) 2013: 17 trials (Observational 3, Not applicable 5, Phase 4 2, Phase 3 4, Phase 2 2, Phase 1/2 1) 2014: 19 trials (Observational 1, Not applicable 8, Phase 4 3, Phase 3 4, Phase 2 3) 2015: 28 trials (Observational 1, Not applicable 9, Phase 4 8, Phase 3 6, Phase 2/3 3, Phase 2 1) 2016: 32 trials (Observational 9, Not applicable 10, Phase 4 8, Phase 3 2, Phase 2 3) 2017: 28 trials (Observational 4, Not applicable 15, Phase 4 6, Phase 3 1, Phase 2 2) 2018: 42 trials (Observational 6, Not applicable 21, Phase 4 9, Phase 3 3, Phase 2/3 1, Phase 2 1, Phase 1 1) 2019: 27 trials (Observational 6, Not applicable 10, Phase 4 10, Phase 2 1) 2020: 36 trials (Observational 5, Not applicable 15, Phase 4 11, Phase 2/3 1, Phase 2 3, Phase 1 1) 2021: 46 trials (Observational 9, Not applicable 23, Phase 4 7, Phase 3 4, Phase 2/3 1, Phase 1/2 1, Phase 1 1) 2022: 46 trials (Observational 5, Not applicable 25, Phase 4 7, Phase 3 4, Phase 2/3 2, Phase 2 3) 2023: 43 trials (Observational 9, Not applicable 20, Phase 4 7, Phase 3 4, Phase 2/3 1, Phase 2 1, Phase 1 1) 2024: 39 trials (Observational 5, Not applicable 23, Phase 4 5, Phase 3 3, Phase 2/3 1, Phase 2 1, Phase 1/2 1) 2025: 55 trials (Observational 9, Not applicable 27, Phase 4 10, Phase 3 2, Phase 2 3, Phase 1/2 1, Phase 1 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 45
2025 55
2024 39
2023 43
2022 46
2021 46
2020 36
2019 27
2018 42
2017 28

Forecast of the full-year count, planned starts included, not rows of this table: about 58 trials starting in 2026 and about 54 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 30 months from start to primary completion across 46 trials still running at the 2026-10-09 snapshot; registered median of 11 months across 423 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Postoperative Nausea and Vomiting trials in? (9)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 10
Phase 1/2 6
Phase 2 40
Phase 2/3 12
Phase 3 53
Phase 4 141
Not applicable 272
Observational 93
Expanded access 1

How many Postoperative Nausea and Vomiting trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 32
Recruiting 46
Enrolling by invitation 4
Active, not recruiting 10
Completed 396

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Postoperative Nausea and Vomiting trials? (3)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Acacia Pharma Ltd 10
GlaxoSmithKline 5
Merck Sharp & Dohme LLC 5

Which drugs are being tested for Postoperative Nausea and Vomiting? (4)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Aprepitant 27
DEXMEDETOMIDINE 16
GRANISETRON 12
PROPOFOL 11

Interventions as named in the registry (11)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Dexamethasone/Dexamethasone acetate 83
Ondansetron - Parts A + B 62
I.V. palonosetron 24
ramosetron 0.6 17
Amisulpride Pill 12

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Postoperative Nausea and Vomiting trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Drowsiness 52 1
Mortality - CDS Email Recommendations 43 1
Mortality - CDS Email + Real Time Recommendations 40 1
PONV 14 1
wound hemorrhage 8 1

Which publications cover Postoperative Nausea and Vomiting? (1,055)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages