Condition (MeSH)
Migraine without Aura
ClinicalTrials.gov lists 109 trials for Migraine without Aura or a narrower condition beneath it. Satsuma Pharmaceuticals, Inc. has the most among industry and government lead sponsors, with 5.
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Trials per phase (log scale)
109 of the 109 trials are tagged with Migraine without Aura itself; the rest are tagged with a narrower condition beneath it.
When did Migraine without Aura trials start? (26)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 13
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 7 |
| 2025 | 3 |
| 2024 | 5 |
| 2023 | 13 |
| 2022 | 8 |
| 2021 | 8 |
| 2020 | 4 |
| 2019 | 2 |
| 2018 | 9 |
| 2017 | 8 |
Showing 10 of 26 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 8 trials starting in 2026 and about 5 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 11 trials still running at the 2026-10-09 snapshot; registered median of 15 months across 71 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Migraine without Aura trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 4 |
| Phase 1/2 | 1 |
| Phase 2 | 9 |
| Phase 2/3 | 1 |
| Phase 3 | 15 |
| Phase 4 | 10 |
| Not applicable | 51 |
| Observational | 18 |
How many Migraine without Aura trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 5 |
| Recruiting | 7 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 4 |
| Completed | 67 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Migraine without Aura trials? (6)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Satsuma Pharmaceuticals, Inc. | 5 |
| Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 3 |
| CoolTech LLC | 2 |
| Minster Research Ltd | 2 |
| Theranica | 2 |
Showing 5 of 6 sponsors.
Which drugs are being tested for Migraine without Aura? (7)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Dihydroergotamine | 5 |
| Levcromakalim | 4 |
| Calcitonin Gene Related Peptide | 3 |
| Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38) | 3 |
| Tonabersat | 2 |
Showing 5 of 7 drugs.
Interventions as named in the registry (8)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Topiramate IR | 4 |
| Rimegepant/BHV3000 | 3 |
| Metclopramide | 3 |
| Acupuncture | 2 |
| Erenumab PFS | 2 |
Showing 5 of 8 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Migraine without Aura trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Acute Myocardial infarction | 1 | 1 |
| Asthma Exacerbation/Pneumonia | 1 | 1 |
| Cholecystitis Acute | 1 | 1 |
| Face oedema | 1 | 1 |
| Hypertension crisis | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Migraine without Aura? (62)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Primary headache epidemiology in children and adolescents: a systematic review and meta-analysis. | The journal of headache and pain | 2023 | Yes |
| Lack of reproducibility of resting-state functional MRI findings in migraine with aura. | Cephalalgia : an international journal of headache | 2023 | Yes |
| Assessment of Erenumab Safety and Efficacy in Patients With Migraine With and Without Aura: A Secondary Analysis of Randomized Clinical Trials. | JAMA neurology | 2022 | Yes |
| Feasibility and effect of mindfulness approach by web for chronic migraine and high-frequency episodic migraine without aura at in adolescents during and after COVID emergency: preliminary findings. | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | 2022 | Yes |
| Effect of Adrenomedullin on Migraine-Like Attacks in Patients With Migraine: A Randomized Crossover Study. | Neurology | 2021 | Yes |
Showing 5 of 62 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.