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Condition (MeSH)

Mononeuropathies

ClinicalTrials.gov lists 925 trials for Mononeuropathies or a narrower condition beneath it.

MeSH D020422 Nervous System Diseases C10
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Phase 1 Phase 1 22 Phase 1/2 Phase 1/2 14 Phase 2 Phase 2 40 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 26 Phase 4 Phase 4 54 Not applicable Not applicable 579 Observational Observational 183 Phase 1 Phase 1 22 Phase 1/2 Phase 1/2 14 Phase 2 Phase 2 40 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 26 Phase 4 Phase 4 54 Not applicable Not applicable 579 Observational Observational 183

Trials per phase (log scale)

7 of the 925 trials are tagged with Mononeuropathies itself; the rest are tagged with a narrower condition beneath it.

Get the Mononeuropathies report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Mononeuropathies trials start? (29)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 4 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 94

1997: 1 trials (Not applicable 1) 1999: 2 trials (Phase 2 2) 2000: 1 trials (Phase 2 1) 2001: 3 trials (Not applicable 1, Phase 2 2) 2002: 5 trials (Observational 2, Not applicable 1, Phase 3 1, Phase 2 1) 2003: 6 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 3 1, Phase 2 1) 2004: 6 trials (Observational 1, Not applicable 1, Phase 4 2, Phase 3 2) 2005: 4 trials (Not applicable 2, Phase 3 1, Phase 2 1) 2006: 16 trials (Observational 3, Not applicable 5, Phase 4 1, Phase 3 2, Phase 2 2, Phase 1/2 2, Phase 1 1) 2007: 10 trials (Observational 1, Not applicable 4, Phase 4 1, Phase 3 1, Phase 1/2 3) 2008: 11 trials (Observational 2, Not applicable 3, Phase 2/3 2, Phase 2 2, Phase 1/2 2) 2009: 22 trials (Observational 2, Not applicable 11, Phase 4 1, Phase 3 2, Phase 2 3, Phase 1/2 1, Phase 1 2) 2010: 14 trials (Observational 2, Not applicable 7, Phase 3 3, Phase 2 2) 2011: 17 trials (Observational 5, Not applicable 6, Phase 3 2, Phase 2 1, Phase 1/2 1, Phase 1 2) 2012: 17 trials (Observational 4, Not applicable 9, Phase 4 2, Phase 2 2) 2013: 31 trials (Observational 3, Not applicable 15, Phase 4 6, Phase 2 6, Phase 1 1) 2014: 24 trials (Observational 8, Not applicable 14, Phase 4 1, Phase 2 1) 2015: 30 trials (Observational 6, Not applicable 18, Phase 4 3, Phase 3 1, Phase 2/3 1, Phase 1 1) 2016: 42 trials (Observational 10, Not applicable 20, Phase 4 4, Phase 3 1, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 3) 2017: 29 trials (Observational 4, Not applicable 18, Phase 4 2, Phase 3 1, Phase 2 2, Phase 1 2) 2018: 54 trials (Observational 8, Not applicable 33, Phase 4 4, Phase 3 2, Phase 2/3 1, Phase 2 1, Phase 1/2 1, Phase 1 4) 2019: 45 trials (Observational 10, Not applicable 29, Phase 4 3, Phase 1/2 2, Phase 1 1) 2020: 49 trials (Observational 12, Not applicable 29, Phase 4 5, Phase 3 1, Phase 2/3 1, Phase 1/2 1) 2021: 67 trials (Observational 13, Not applicable 49, Phase 4 2, Phase 3 2, Phase 1 1) 2022: 77 trials (Observational 9, Not applicable 60, Phase 4 5, Phase 2 2, Phase 1 1) 2023: 94 trials (Observational 24, Not applicable 65, Phase 4 3, Phase 3 1, Phase 2/3 1) 2024: 72 trials (Observational 19, Not applicable 53) 2025: 85 trials (Observational 17, Not applicable 59, Phase 4 5, Phase 2 2, Phase 1 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 85
2025 85
2024 72
2023 94
2022 77
2021 67
2020 49
2019 45
2018 54
2017 29

Forecast of the full-year count, planned starts included, not rows of this table: about 110 trials starting in 2026 and about 91 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 33 months from start to primary completion across 73 trials still running at the 2026-10-09 snapshot; registered median of 13 months across 560 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Mononeuropathies trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 22
Phase 1/2 14
Phase 2 40
Phase 2/3 7
Phase 3 26
Phase 4 54
Not applicable 579
Observational 183

How many Mononeuropathies trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 74
Recruiting 88
Enrolling by invitation 12
Active, not recruiting 21
Completed 523

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Mononeuropathies? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
METHYLPREDNISOLONE 10
Corticosteroid 7
DEXMEDETOMIDINE 5

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
L:Lidocaine 13
Acupuncture 11
[PRP] platelet rich plasma 11
Exercise 9
Steroid (dexamethasone) Injection 8

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Mononeuropathies trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Coginitve 12 1
Fall 10 2
PAIN IN EXTREMITY 10 1
BACK PAIN 7 1
Cardiac 7 1

Which publications cover Mononeuropathies? (11)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Progressive Multiple Mononeuropathy in a Patient With Familial Transthyretin Amyloidosis After Liver Transplantation. Journal of clinical neuromuscular disease 2022 Yes
Long-term treatment of chronic orofacial, pudendal, and central neuropathic limb pain with repetitive transcranial magnetic stimulation of the motor cortex. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2020 Yes
Acute mononeuropathy in a child with newly diagnosed type 1 diabetes mellitus. Journal of pediatric endocrinology & metabolism : JPEM 2015 Yes
Mononeuritis multiplex predicts the need for immunosuppressive or immunomodulatory drugs for EGPA, PAN and MPA patients without poor-prognosis factors. Autoimmunity reviews 2014 Yes
Italian multicentre study of peroneal mononeuropathy: multiperspective follow-up. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2009 Yes

Sub-conditions in MeSH (7)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.

Browse all condition evidence pages