Condition (MeSH)
Multiple Sclerosis, Chronic Progressive
ClinicalTrials.gov lists 242 trials for Multiple Sclerosis, Chronic Progressive or a narrower condition beneath it. Novartis Pharmaceuticals has the most among industry and government lead sponsors, with 13.
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Trials per phase
1 more section with rows
242 of the 242 trials are tagged with Multiple Sclerosis, Chronic Progressive itself; the rest are tagged with a narrower condition beneath it.
When did Multiple Sclerosis, Chronic Progressive trials start? (25)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 19
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 19 |
| 2025 | 12 |
| 2024 | 19 |
| 2023 | 14 |
| 2022 | 18 |
| 2021 | 15 |
| 2020 | 9 |
| 2019 | 13 |
| 2018 | 15 |
| 2017 | 14 |
Showing 10 of 25 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 19 trials starting in 2026 and about 17 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 33 trials still running at the 2026-10-09 snapshot; registered median of 34 months across 148 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Multiple Sclerosis, Chronic Progressive trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 36 |
| Phase 1/2 | 24 |
| Phase 2 | 43 |
| Phase 2/3 | 8 |
| Phase 3 | 30 |
| Phase 4 | 5 |
| Not applicable | 49 |
| Observational | 46 |
| Expanded access | 1 |
How many Multiple Sclerosis, Chronic Progressive trials are recruiting? (10)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 12 |
| Recruiting | 29 |
| Enrolling by invitation | 3 |
| Active, not recruiting | 20 |
| Completed | 120 |
Showing 5 of 10 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Multiple Sclerosis, Chronic Progressive trials? (10)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Novartis Pharmaceuticals | 13 |
| Hoffmann-La Roche | 9 |
| Biogen | 5 |
| National Institute of Allergy and Infectious Diseases (NIAID) | 5 |
| Bayer | 4 |
Showing 5 of 10 sponsors.
Which drugs are being tested for Multiple Sclerosis, Chronic Progressive? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| RITUXIMAB | 8 |
| METHYLPREDNISOLONE | 7 |
| BAF312 | 5 |
| dirucotide | 3 |
| SIMVASTATIN | 3 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Ocrelizumab SC | 16 |
| Acute Intermittent Hypoxia (AIH) | 4 |
| SC interferon beta-1b | 4 |
| natalizumab SC | 3 |
| Acyclovir 5% | 3 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Multiple Sclerosis, Chronic Progressive trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Urinary tract infection | 174 | 13 |
| Multiple sclerosis relapse | 142 | 10 |
| Basal cell carcinoma | 114 | 4 |
| Pneumonia | 79 | 14 |
| Multiple sclerosis | 53 | 6 |
Showing 5 of 10 adverse events.
Which publications cover Multiple Sclerosis, Chronic Progressive? (267)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Lipoic Acid for Treatment of Progressive Multiple Sclerosis: A Phase 2 Randomized Clinical Trial. | Neurology | 2026 | Yes |
| Subcutaneous Ocrelizumab in Patients With Multiple Sclerosis: Results of the Phase 3 OCARINA II Study. | Neurology | 2025 | Yes |
| Bile acid metabolites predict multiple sclerosis progression and supplementation is safe in progressive disease. | Med (New York, N.Y.) | 2025 | Yes |
| Study protocol: Exploratory trial of Forza™, an osmotin-based nutraceutical as adjuvant for the treatment of progressive multiple sclerosis. | PloS one | 2025 | Yes |
| Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis. | The New England journal of medicine | 2025 | Yes |
Showing 5 of 267 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.