Condition (MeSH)
Lewy Body Disease
ClinicalTrials.gov lists 236 trials for Lewy Body Disease or a narrower condition beneath it. Axovant Sciences Ltd. has the most among industry and government lead sponsors, with 6.
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Trials per phase (log scale)
1 more section with rows
236 of the 236 trials are tagged with Lewy Body Disease itself; the rest are tagged with a narrower condition beneath it.
When did Lewy Body Disease trials start? (25)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 29
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 15 |
| 2025 | 13 |
| 2024 | 21 |
| 2023 | 24 |
| 2022 | 19 |
| 2021 | 29 |
| 2020 | 15 |
| 2019 | 15 |
| 2018 | 12 |
| 2017 | 8 |
Showing 10 of 25 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 14 trials starting in 2026 and about 14 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored. The 2026 forecast is below the 15 already registered with a 2026 start date: at the cutoff, 4 trials were already registered to start in October to December, more than the method's monthly average allows for, and the method does not use those planned starts.
Prediction, not a registry value: median of 36 months from start to primary completion across 28 trials still running at the 2026-10-09 snapshot; registered median of 29 months across 113 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Lewy Body Disease trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 9 |
| Phase 1/2 | 4 |
| Phase 2 | 30 |
| Phase 2/3 | 3 |
| Phase 3 | 7 |
| Phase 4 | 12 |
| Not applicable | 87 |
| Observational | 83 |
| Expanded access | 1 |
How many Lewy Body Disease trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 14 |
| Recruiting | 54 |
| Enrolling by invitation | 11 |
| Active, not recruiting | 11 |
| Completed | 105 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Lewy Body Disease trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Axovant Sciences Ltd. | 6 |
| Eisai Co., Ltd. | 5 |
| Danish Dementia Research Centre | 3 |
| EIP Pharma Inc | 3 |
| Eisai Inc. | 3 |
Which drugs are being tested for Lewy Body Disease? (8)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| SB-742457 | 3 |
| Nelotanserin | 3 |
| Irsenontrine | 3 |
| Neflamapimod | 3 |
| zervimesine | 2 |
Showing 5 of 8 drugs.
Interventions as named in the registry (7)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Donepezil HCI (drug) | 7 |
| MRI | 4 |
| memantine ER | 3 |
| Active drug: pimavanserin 17mg (2 strength tablets) | 2 |
| Nilotinib Pill | 2 |
Showing 5 of 7 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Lewy Body Disease trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Overnight hospitalization | 334 | 1 |
| Severe fall | 83 | 1 |
| Pneumonia | 11 | 6 |
| Urinary tract infection | 11 | 3 |
| Fall | 7 | 5 |
Showing 5 of 10 adverse events.
Which publications cover Lewy Body Disease? (140)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Peripheral Single-Cell Immune Characteristics Contribute to the Diagnosis of Alzheimer's Disease and Dementia With Lewy Bodies. | CNS neuroscience & therapeutics | 2025 | Yes |
| Functional Connectivity Changes Associated With Depression in Dementia With Lewy Bodies. | International journal of geriatric psychiatry | 2025 | Yes |
| Caregiver experiences after the death of a person with dementia with Lewy bodies: A mixed-methods analysis. | Journal of Alzheimer's disease : JAD | 2025 | Yes |
| Salience and frontoparietal network impairments across disease stages in dementia with Lewy bodies: A comparative functional MRI study with Alzheimer's disease. | Journal of Alzheimer's disease : JAD | 2025 | Yes |
| Safety and efficacy of pimavanserin in patients with Lewy body dementia experiencing dementia-related psychosis in the HARMONY study. | BMC neurology | 2025 | Yes |
Showing 5 of 140 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.