Condition (MeSH)
Chronobiology Disorders
ClinicalTrials.gov lists 236 trials for Chronobiology Disorders or a narrower condition beneath it. Vanda Pharmaceuticals has the most among industry and government lead sponsors, with 11.
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Trials per phase (log scale)
101 of the 236 trials are tagged with Chronobiology Disorders itself; the rest are tagged with a narrower condition beneath it.
When did Chronobiology Disorders trials start? (28)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 24
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 7 |
| 2025 | 14 |
| 2024 | 24 |
| 2023 | 17 |
| 2022 | 20 |
| 2021 | 18 |
| 2020 | 14 |
| 2019 | 15 |
| 2018 | 16 |
| 2017 | 15 |
Showing 10 of 28 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 10 trials starting in 2026 and about 13 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 27 trials still running at the 2026-10-09 snapshot; registered median of 23 months across 150 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Chronobiology Disorders trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 11 |
| Phase 2/3 | 1 |
| Phase 3 | 15 |
| Phase 4 | 12 |
| Not applicable | 124 |
| Observational | 65 |
How many Chronobiology Disorders trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 7 |
| Recruiting | 26 |
| Enrolling by invitation | 4 |
| Active, not recruiting | 8 |
| Completed | 141 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Chronobiology Disorders trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Vanda Pharmaceuticals | 11 |
| Neurim Pharmaceuticals Ltd. | 3 |
| Takeda | 3 |
Which drugs are being tested for Chronobiology Disorders? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Tasimelteon | 10 |
| Ramelteon | 5 |
| Armodafinil | 2 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Melatonin PR | 18 |
| Observational | 2 |
| Lemborexant Pill | 2 |
| Valerian-Hop Extract | 1 |
| Melatonin treatment | 1 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Chronobiology Disorders trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Surgeries/Procedures | 30 | 1 |
| Hospital Admissions | 8 | 1 |
| Emergency Department Visits | 7 | 1 |
| Deaths | 5 | 1 |
| SAE -Serious adverse event | 4 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Chronobiology Disorders? (73)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Sleep and circadian disturbances in children with neurodevelopmental disorders. | Nature reviews. Neurology | 2025 | Yes |
| The efficacy of a transdiagnostic sleep intervention for outpatients with sleep problems and depression, bipolar disorder, or attention deficit disorder: study protocol for a randomized controlled trial. | Trials | 2024 | Yes |
| Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology. | Bipolar disorders | 2022 | Yes |
| Circadian rhythm and disease: Relationship, new insights, and future perspectives. | Journal of cellular physiology | 2022 | Yes |
| Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1. | International journal of molecular sciences | 2022 | Yes |
Showing 5 of 73 publications.
Sub-conditions in MeSH (3)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.