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Condition (MeSH)

Metabolic Syndrome

ClinicalTrials.gov lists 2,091 trials for Metabolic Syndrome or a narrower condition beneath it.

MeSH D024821 Nutritional and Metabolic Diseases C18
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Phase 1 Phase 1 48 Phase 1/2 Phase 1/2 25 Phase 2 Phase 2 107 Phase 2/3 Phase 2/3 34 Phase 3 Phase 3 71 Phase 4 Phase 4 139 Not applicable Not applicable 1,166 Observational Observational 499 Phase 1 Phase 1 48 Phase 1/2 Phase 1/2 25 Phase 2 Phase 2 107 Phase 2/3 Phase 2/3 34 Phase 3 Phase 3 71 Phase 4 Phase 4 139 Not applicable Not applicable 1,166 Observational Observational 499

Trials per phase (log scale)

2 more sections with rows

2,091 of the 2,091 trials are tagged with Metabolic Syndrome itself; the rest are tagged with a narrower condition beneath it.

Get the Metabolic Syndrome report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Metabolic Syndrome trials start? (34)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational
  • Other (Unknown)

Top of scale: 112

1991: 1 trials (Phase 2 1) 1993: 1 trials (Observational 1) 1994: 1 trials (Observational 1) 1996: 1 trials (Observational 1) 1997: 1 trials (Observational 1) 1998: 1 trials (Phase 2 1) 1999: 2 trials (Observational 1, Phase 3 1) 2000: 8 trials (Observational 3, Not applicable 3, Phase 2 2) 2001: 10 trials (Observational 1, Not applicable 5, Phase 4 1, Phase 2 3) 2002: 9 trials (Observational 4, Not applicable 2, Phase 4 1, Phase 3 2) 2003: 22 trials (Observational 6, Not applicable 7, Phase 4 3, Phase 3 1, Phase 2 3, Phase 1/2 2) 2004: 50 trials (Observational 5, Not applicable 19, Phase 4 11, Phase 3 3, Phase 2/3 1, Phase 2 7, Phase 1/2 2, Phase 1 2) 2005: 59 trials (Observational 17, Not applicable 16, Phase 4 8, Phase 3 7, Phase 2/3 2, Phase 2 6, Phase 1/2 2, Phase 1 1) 2006: 79 trials (Observational 12, Not applicable 33, Phase 4 15, Phase 3 4, Phase 2/3 3, Phase 2 6, Phase 1/2 1, Phase 1 5) 2007: 87 trials (Observational 22, Not applicable 37, Phase 4 12, Phase 3 6, Phase 2/3 1, Phase 2 6, Phase 1/2 1, Phase 1 2) 2008: 85 trials (Observational 20, Not applicable 32, Phase 4 12, Phase 3 8, Phase 2/3 4, Phase 2 8, Phase 1/2 1) 2009: 89 trials (Observational 25, Not applicable 42, Phase 4 7, Phase 3 2, Phase 2/3 4, Phase 2 4, Phase 1/2 3, Phase 1 2) 2010: 81 trials (Observational 19, Not applicable 44, Phase 4 7, Phase 3 3, Phase 2 4, Phase 1/2 1, Phase 1 3) 2011: 74 trials (Observational 18, Not applicable 36, Phase 4 6, Phase 3 4, Phase 2/3 1, Phase 2 4, Phase 1/2 2, Phase 1 3) 2012: 86 trials (Observational 33, Not applicable 38, Phase 4 5, Phase 3 1, Phase 2/3 2, Phase 2 3, Phase 1 4) 2013: 94 trials (Observational 20, Not applicable 50, Phase 4 6, Phase 3 7, Phase 2/3 1, Phase 2 6, Phase 1 4) 2014: 107 trials (Observational 26, Not applicable 57, Phase 4 4, Phase 3 4, Phase 2/3 3, Phase 2 8, Phase 1/2 2, Phase 1 3) 2015: 85 trials (Observational 22, Not applicable 49, Phase 4 4, Phase 2/3 1, Phase 2 6, Phase 1/2 1, Phase 1 2) 2016: 76 trials (Observational 16, Not applicable 49, Phase 4 3, Phase 3 1, Phase 2/3 2, Phase 2 1, Phase 1 4) 2017: 87 trials (Other 1, Observational 14, Not applicable 65, Phase 3 1, Phase 2/3 2, Phase 2 1, Phase 1/2 1, Phase 1 2) 2018: 91 trials (Observational 16, Not applicable 63, Phase 4 4, Phase 3 1, Phase 2/3 1, Phase 2 4, Phase 1/2 2) 2019: 92 trials (Observational 15, Not applicable 65, Phase 4 4, Phase 3 2, Phase 2/3 2, Phase 2 3, Phase 1 1) 2020: 82 trials (Observational 22, Not applicable 51, Phase 4 4, Phase 3 2, Phase 2/3 1, Phase 2 2) 2021: 104 trials (Observational 23, Not applicable 74, Phase 4 3, Phase 3 1, Phase 2 3) 2022: 97 trials (Observational 19, Not applicable 68, Phase 4 3, Phase 3 2, Phase 2 2, Phase 1 3) 2023: 105 trials (Observational 24, Not applicable 69, Phase 4 4, Phase 3 2, Phase 2 3, Phase 1/2 2, Phase 1 1) 2024: 112 trials (Observational 28, Not applicable 74, Phase 4 3, Phase 2 4, Phase 1/2 1, Phase 1 2) 2025: 110 trials (Observational 34, Not applicable 62, Phase 4 4, Phase 3 3, Phase 2 4, Phase 1/2 1, Phase 1 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 90
2025 110
2024 112
2023 105
2022 97
2021 104
2020 82
2019 92
2018 91
2017 87

Forecast of the full-year count, planned starts included, not rows of this table: about 110 trials starting in 2026 and about 110 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 129 trials still running at the 2026-10-09 snapshot; registered median of 20 months across 1,363 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Metabolic Syndrome trials in? (10)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 48
Phase 1/2 25
Phase 2 107
Phase 2/3 34
Phase 3 71
Phase 4 139
Not applicable 1,166
Observational 499
Expanded access 1
Unknown 1

How many Metabolic Syndrome trials are recruiting? (10)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 83
Recruiting 183
Enrolling by invitation 22
Active, not recruiting 57
Available 1

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Metabolic Syndrome? (6)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Aripiprazole 11
ATORVASTATIN 10
Fish Oil 9
Berberine 8
ROSUVASTATIN 8

Interventions as named in the registry (9)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
1% Metformin 39
Exercise 25
Pioglitazone - TZD 14
Rosiglitazone XR 10
Weight loss 10

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Metabolic Syndrome trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Any Cancer 283 1
Chest pain 143 1
Non-basal-cell skin cancer (not known if SAE) 86 1
Pneumonia 58 2
Indigestions 55 1

Which publications cover Metabolic Syndrome? (2,653)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages