Condition (MeSH)
Metabolic Syndrome
ClinicalTrials.gov lists 2,091 trials for Metabolic Syndrome or a narrower condition beneath it.
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Trials per phase (log scale)
2 more sections with rows
2,091 of the 2,091 trials are tagged with Metabolic Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Metabolic Syndrome trials start? (34)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
- Other (Unknown)
Top of scale: 112
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 90 |
| 2025 | 110 |
| 2024 | 112 |
| 2023 | 105 |
| 2022 | 97 |
| 2021 | 104 |
| 2020 | 82 |
| 2019 | 92 |
| 2018 | 91 |
| 2017 | 87 |
Showing 10 of 34 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 110 trials starting in 2026 and about 110 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 129 trials still running at the 2026-10-09 snapshot; registered median of 20 months across 1,363 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Metabolic Syndrome trials in? (10)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 48 |
| Phase 1/2 | 25 |
| Phase 2 | 107 |
| Phase 2/3 | 34 |
| Phase 3 | 71 |
| Phase 4 | 139 |
| Not applicable | 1,166 |
| Observational | 499 |
| Expanded access | 1 |
| Unknown | 1 |
How many Metabolic Syndrome trials are recruiting? (10)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 83 |
| Recruiting | 183 |
| Enrolling by invitation | 22 |
| Active, not recruiting | 57 |
| Available | 1 |
Showing 5 of 10 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which drugs are being tested for Metabolic Syndrome? (6)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Aripiprazole | 11 |
| ATORVASTATIN | 10 |
| Fish Oil | 9 |
| Berberine | 8 |
| ROSUVASTATIN | 8 |
Showing 5 of 6 drugs.
Interventions as named in the registry (9)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| 1% Metformin | 39 |
| Exercise | 25 |
| Pioglitazone - TZD | 14 |
| Rosiglitazone XR | 10 |
| Weight loss | 10 |
Showing 5 of 9 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Metabolic Syndrome trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Any Cancer | 283 | 1 |
| Chest pain | 143 | 1 |
| Non-basal-cell skin cancer (not known if SAE) | 86 | 1 |
| Pneumonia | 58 | 2 |
| Indigestions | 55 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Metabolic Syndrome? (2,653)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Association between self-reported behavioral habits and their respective behavioral risk factors in individuals with metabolic syndrome. | Appetite | 2026 | Yes |
| Genotype-guided dual antiplatelet therapy in minor stroke or transient ischemic attack with metabolic syndrome: A post hoc analysis of CHANCE-2. | Diabetes, obesity & metabolism | 2026 | Yes |
| Lifestyle Intervention for Sustained Remission of Metabolic Syndrome: A Randomized Clinical Trial. | JAMA internal medicine | 2026 | Yes |
| The impact of olive oil polyphenol supplementation on metabolic syndrome parameters The OleoMetS study: A randomized, controlled clinical trial. | Clinical nutrition ESPEN | 2026 | Yes |
| Traditional Chinese Medicine Syndrome Differentiation of Adult Patients With Type 2 Diabetes and Metabolic Syndrome: Protocol for a Cross-Sectional Study. | JMIR research protocols | 2026 | Yes |
Showing 5 of 2,653 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, prevalence, rare-disease identity, and sub-conditions in mesh.