Condition (MeSH)
Trigeminal Autonomic Cephalalgias
ClinicalTrials.gov lists 124 trials for Trigeminal Autonomic Cephalalgias or a narrower condition beneath it. Autonomic Technologies, Inc. has the most among industry and government lead sponsors, with 6.
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Trials per phase
13 of the 124 trials are tagged with Trigeminal Autonomic Cephalalgias itself; the rest are tagged with a narrower condition beneath it.
When did Trigeminal Autonomic Cephalalgias trials start? (24)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 12
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 9 |
| 2025 | 6 |
| 2024 | 3 |
| 2023 | 11 |
| 2022 | 4 |
| 2021 | 12 |
| 2020 | 7 |
| 2019 | 7 |
| 2018 | 5 |
| 2017 | 7 |
Showing 10 of 24 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 8 trials starting in 2026 and about 7 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored. The 2026 forecast is below the 9 already registered with a 2026 start date: at the cutoff, 3 trials were already registered to start in October to December, more than the method's monthly average allows for, and the method does not use those planned starts.
Prediction, not a registry value: median of 36 months from start to primary completion across 13 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 79 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Trigeminal Autonomic Cephalalgias trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 4 |
| Phase 1/2 | 5 |
| Phase 2 | 12 |
| Phase 2/3 | 3 |
| Phase 3 | 16 |
| Phase 4 | 6 |
| Not applicable | 45 |
| Observational | 33 |
How many Trigeminal Autonomic Cephalalgias trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 4 |
| Recruiting | 18 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 3 |
| Completed | 62 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Trigeminal Autonomic Cephalalgias trials? (6)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Autonomic Technologies, Inc. | 6 |
| ElectroCore INC | 3 |
| Eli Lilly and Company | 3 |
| Salvia BioElectronics | 3 |
| Teva Branded Pharmaceutical Products R&D, Inc. | 3 |
Showing 5 of 6 sponsors.
Which drugs are being tested for Trigeminal Autonomic Cephalalgias? (6)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Galcanezumab | 3 |
| Eptinezumab | 3 |
| Fremanezumab | 3 |
| Civamide | 2 |
| PMI-150 (intranasal ketamine) | 2 |
Showing 5 of 6 drugs.
Interventions as named in the registry (9)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| type A botulinum toxin | 3 |
| SR verapamil | 2 |
| Capsaicin 8% | 2 |
| Erenumab PFS | 2 |
| BLOOD SAMPLE | 2 |
Showing 5 of 9 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Trigeminal Autonomic Cephalalgias trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Cluster headache | 14 | 7 |
| Cholecystitis | 3 | 3 |
| Hospitalization for cluster headache pain | 3 | 1 |
| Acute respiratory failure | 2 | 2 |
| Anaphylactic reaction | 2 | 2 |
Showing 5 of 10 adverse events.
Which publications cover Trigeminal Autonomic Cephalalgias? (8)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| A randomized trial of telemedicine efficacy and safety for nonacute headaches. | Neurology | 2017 | Yes |
| Sphenopalatine Ganglion Block in the Management of Chronic Headaches. | Current pain and headache reports | 2017 | Yes |
| The epidemiology of primary headache disorders. | Seminars in neurology | 2010 | Yes |
| A new trigemino-nociceptive stimulation model for event-related fMRI. | Cephalalgia : an international journal of headache | 2010 | Yes |
| EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. | European journal of neurology | 2006 | Yes |
Showing 5 of 8 publications.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Trigeminal autonomic cephalalgia | 157843 | Exact | Orphadata Science knowledge files, Product 1 |
| Trigeminal autonomic cephalalgia | 157843 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Sub-conditions in MeSH (2)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence.