Condition (MeSH)
Heart Failure, Systolic
ClinicalTrials.gov lists 222 trials for Heart Failure, Systolic or a narrower condition beneath it. Novartis Pharmaceuticals has the most among industry and government lead sponsors, with 6.
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Trials per phase (log scale)
222 of the 222 trials are tagged with Heart Failure, Systolic itself; the rest are tagged with a narrower condition beneath it.
When did Heart Failure, Systolic trials start? (26)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 21
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 16 |
| 2025 | 17 |
| 2024 | 12 |
| 2023 | 17 |
| 2022 | 6 |
| 2021 | 21 |
| 2020 | 14 |
| 2019 | 13 |
| 2018 | 18 |
| 2017 | 15 |
Showing 10 of 26 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 20 trials starting in 2026 and about 18 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 29 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 125 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Heart Failure, Systolic trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 8 |
| Phase 1/2 | 5 |
| Phase 2 | 14 |
| Phase 2/3 | 4 |
| Phase 3 | 10 |
| Phase 4 | 29 |
| Not applicable | 97 |
| Observational | 55 |
How many Heart Failure, Systolic trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 14 |
| Recruiting | 25 |
| Enrolling by invitation | 6 |
| Active, not recruiting | 8 |
| Completed | 95 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Heart Failure, Systolic trials? (5)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Novartis Pharmaceuticals | 6 |
| Abbott Medical Devices | 2 |
| AstraZeneca | 2 |
| BioCardia, Inc. | 2 |
| Boston Scientific Corporation | 2 |
Which drugs are being tested for Heart Failure, Systolic? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| BMS-512148 | 4 |
| Enalapril | 4 |
| Nicotinamide Riboside | 2 |
| Digoxin | 2 |
| Levosimendan | 2 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Valsartan and Sacubitril | 6 |
| LCZ696A | 5 |
| Ferricarboxymaltose | 4 |
| Anakinra alone (stages 2b/3) | 2 |
| Nitrate-deplete beetroot juice | 2 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Heart Failure, Systolic trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Cardiac Failure Congestive | 742 | 1 |
| Arrhythmia | 235 | 1 |
| Infection | 164 | 1 |
| Pneumonia | 139 | 5 |
| Renal Failure Acute | 127 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Heart Failure, Systolic? (182)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Estimated Glomerular Filtration Rate and Implantable Cardioverter-Defibrillator in Nonischemic Systolic Heart Failure: Extended Follow-Up of DANISH. | Journal of the American Heart Association | 2024 | Yes |
| Efficacy of Dapagliflozin According to Heart Rate: A Patient-Level Pooled Analysis of DAPA-HF and DELIVER. | Circulation. Heart failure | 2023 | Yes |
| Effect of adaptive servo-ventilation for central sleep apnoea in systolic heart failure on muscle sympathetic nerve activity: a SERVE-HF randomised ancillary study. | The European respiratory journal | 2023 | Yes |
| Racial Inequities in Access to Ventricular Assist Device and Transplant Persist After Consideration for Preferences for Care: A Report From the REVIVAL Study. | Circulation. Heart failure | 2023 | Yes |
| Early predicting improvement of severe systolic heart failure by left atrial volume. | Heart and vessels | 2023 | Yes |
Showing 5 of 182 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.