Condition (MeSH)
Angioedemas, Hereditary
ClinicalTrials.gov lists 177 trials for Angioedemas, Hereditary or a narrower condition beneath it. Shire has the most among industry and government lead sponsors, with 39.
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Trials per phase
1 more section with rows
169 of the 177 trials are tagged with Angioedemas, Hereditary itself; the rest are tagged with a narrower condition beneath it.
When did Angioedemas, Hereditary trials start? (25)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 17
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 9 |
| 2025 | 14 |
| 2024 | 9 |
| 2023 | 8 |
| 2022 | 17 |
| 2021 | 15 |
| 2020 | 5 |
| 2019 | 7 |
| 2018 | 11 |
| 2017 | 4 |
Showing 10 of 25 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 10 trials starting in 2026 and about 11 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 17 trials still running at the 2026-10-09 snapshot; registered median of 20 months across 129 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Angioedemas, Hereditary trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 19 |
| Phase 1/2 | 6 |
| Phase 2 | 25 |
| Phase 2/3 | 8 |
| Phase 3 | 55 |
| Phase 4 | 11 |
| Not applicable | 3 |
| Observational | 43 |
| Expanded access | 7 |
How many Angioedemas, Hereditary trials are recruiting? (11)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 3 |
| Recruiting | 13 |
| Enrolling by invitation | 5 |
| Active, not recruiting | 12 |
| Available | 3 |
Showing 5 of 11 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Angioedemas, Hereditary trials? (13)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Shire | 39 |
| Takeda | 19 |
| BioCryst Pharmaceuticals | 17 |
| CSL Behring | 15 |
| KalVista Pharmaceuticals, Ltd. | 13 |
Showing 5 of 13 sponsors.
Which drugs are being tested for Angioedemas, Hereditary? (12)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| C1 esterase inhibitor [human] (C1INH-nf) | 13 |
| Icatibant | 11 |
| Berotralstat | 11 |
| Lanadelumab | 9 |
| Sebetralstat | 9 |
Showing 5 of 12 drugs.
Interventions as named in the registry (3)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| C1 Esterase Inhibitor | 6 |
| C1 inhibitor concentrate | 3 |
| rhC1INH | 3 |
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Angioedemas, Hereditary trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Hereditary angioedema | 42 | 18 |
| hereditary angioedema | 17 | 1 |
| Hereditary Angioedema | 14 | 2 |
| Pneumonia | 10 | 7 |
| Gastroenteritis | 8 | 5 |
Showing 5 of 10 adverse events.
Which publications cover Angioedemas, Hereditary? (107)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Effective long-term prophylaxis with lanadelumab in adolescents with hereditary angioedema: EMPOWER/ENABLE. | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology | 2025 | Yes |
| Becoming attack-free further improves health-related quality of life in patients with hereditary angioedema receiving garadacimab. | Allergy and asthma proceedings | 2025 | Yes |
| Lanadelumab's impact on hereditary angioedema control and quality of life across disease activity subgroups: Real-world evidence. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology | 2025 | Yes |
| Long-Term Safety and Effectiveness of Sebetralstat: Interim Analysis of KONFIDENT-S Open-label Extension. | The journal of allergy and clinical immunology. In practice | 2025 | Yes |
| CRISPR-Based Therapy for Hereditary Angioedema. | The New England journal of medicine | 2025 | Yes |
Showing 5 of 107 publications.
Prevalence (12)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Hereditary angioedema | Point prevalence | 1-9 / 100 000 | Europe | Not stated | Exact |
| Hereditary angioedema | Point prevalence | 1-9 / 100 000 | Spain | Not stated | Unspecified |
| Hereditary angioedema | Point prevalence | 1-9 / 100 000 | Norway | Not stated | Unspecified |
| Hereditary angioedema | Point prevalence | 1-9 / 100 000 | Norway | Not stated | Exact |
| Hereditary angioedema | Point prevalence | 1-9 / 100 000 | Denmark | Not stated | Exact |
Showing 5 of 12 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Hereditary angioedema | 91378 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Hereditary angioedema | 91378 | Exact | Orphadata Science knowledge files, Product 1 |
Sub-conditions in MeSH (2)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.