Condition (MeSH)
Postural Orthostatic Tachycardia Syndrome
ClinicalTrials.gov lists 134 trials for Postural Orthostatic Tachycardia Syndrome or a narrower condition beneath it. National Institute of Neurological Disorders and Stroke (NINDS) has the most among industry and government lead sponsors, with 3.
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Trials per phase (log scale)
134 of the 134 trials are tagged with Postural Orthostatic Tachycardia Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Postural Orthostatic Tachycardia Syndrome trials start? (26)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 17
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 9 |
| 2025 | 12 |
| 2024 | 10 |
| 2023 | 12 |
| 2022 | 17 |
| 2021 | 6 |
| 2020 | 3 |
| 2019 | 5 |
| 2018 | 4 |
| 2017 | 7 |
Showing 10 of 26 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 9 trials starting in 2026 and about 10 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 16 trials still running at the 2026-10-09 snapshot; registered median of 35 months across 67 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Postural Orthostatic Tachycardia Syndrome trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 12 |
| Phase 1/2 | 4 |
| Phase 2 | 15 |
| Phase 2/3 | 1 |
| Phase 3 | 2 |
| Phase 4 | 4 |
| Not applicable | 64 |
| Observational | 32 |
How many Postural Orthostatic Tachycardia Syndrome trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 13 |
| Recruiting | 27 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 22 |
| Completed | 53 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Postural Orthostatic Tachycardia Syndrome trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | 3 |
Which drugs are being tested for Postural Orthostatic Tachycardia Syndrome? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Pyridostigmine | 3 |
| PHENYLEPHRINE | 3 |
| Isoproterenol | 2 |
| Droxidopa | 2 |
| Modafinil | 2 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Propranolol PO | 4 |
| Ivabradine Pill | 4 |
| mirabegron OCAS | 2 |
| Medications that modulate heart rate and blood pressure | 1 |
| Compare change is SVC and SMA flow due to GIP antagonist GIP(3-30)NH2 | 1 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Postural Orthostatic Tachycardia Syndrome trials report? (4)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Magnetic resonance imaging of head abnormal (finding) | 1 | 1 |
| Ovarian Cyst rupture | 1 | 1 |
| Pneumonia | 1 | 1 |
| Severe Headache | 1 | 1 |
Which publications cover Postural Orthostatic Tachycardia Syndrome? (107)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| A Community-Based Trial of Commercially Available Compression Tights in Patients With Postural Orthostatic Tachycardia Syndrome. | JACC. Clinical electrophysiology | 2025 | Yes |
| Assessing symptom improvement in patients with postural orthostatic tachycardia syndrome (POTS) following a 16-week structured exercise programme: a protocol for a randomised cross-over trial in a clinical outpatient setting. | BMJ open | 2025 | Yes |
| Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial. | JACC. Clinical electrophysiology | 2024 | Yes |
| Prevalence of orthostatic intolerance in long covid clinic patients and healthy volunteers: A multicenter study. | Journal of medical virology | 2024 | Yes |
| Long-Term POTS Outcomes Survey: Diagnosis, Therapy, and Clinical Outcomes. | Journal of the American Heart Association | 2024 | Yes |
Showing 5 of 107 publications.
Prevalence (2)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Postural orthostatic tachycardia syndrome due to NET deficiency | Cases families | Worldwide | Not stated | Unspecified | |
| Postural orthostatic tachycardia syndrome due to NET deficiency | Point prevalence | <1 / 1 000 000 | Worldwide | Not stated | Unspecified |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: rare-disease identity and sub-conditions in mesh.