Condition (MeSH)
Plaque, Amyloid
ClinicalTrials.gov lists 270 trials for Plaque, Amyloid or a narrower condition beneath it. Novartis Pharmaceuticals has the most among industry and government lead sponsors, with 16.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
1 more section with rows
270 of the 270 trials are tagged with Plaque, Amyloid itself; the rest are tagged with a narrower condition beneath it.
When did Plaque, Amyloid trials start? (26)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 2 trials are registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
- Other (Unknown)
Top of scale: 21
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 24 |
| 2025 | 13 |
| 2024 | 13 |
| 2023 | 16 |
| 2022 | 16 |
| 2021 | 15 |
| 2020 | 10 |
| 2019 | 10 |
| 2018 | 10 |
| 2017 | 7 |
Showing 10 of 26 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 26 trials starting in 2026 and about 20 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 17 trials still running at the 2026-10-09 snapshot; registered median of 17 months across 182 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Plaque, Amyloid trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 23 |
| Phase 1/2 | 6 |
| Phase 2 | 38 |
| Phase 2/3 | 3 |
| Phase 3 | 42 |
| Phase 4 | 20 |
| Not applicable | 82 |
| Observational | 54 |
| Unknown | 2 |
How many Plaque, Amyloid trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 14 |
| Recruiting | 25 |
| Enrolling by invitation | 4 |
| Active, not recruiting | 6 |
| Completed | 176 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Plaque, Amyloid trials? (10)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Novartis Pharmaceuticals | 16 |
| Colgate Palmolive | 14 |
| Eli Lilly and Company | 9 |
| Koite Health Oy | 6 |
| Home Skinovations Ltd. | 4 |
Showing 5 of 10 sponsors.
Which drugs are being tested for Plaque, Amyloid? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Florbetaben F18 | 6 |
| Donanemab | 4 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Secukinmab | 14 |
| Stannous Fluoride Toothpaste | 6 |
| Colgate Cavity Protection Toothpaste | 5 |
| F-18 florbetapir | 5 |
| Chlorhexidine mouthwash | 4 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Plaque, Amyloid trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Peripheral artery stenosis | 88 | 1 |
| Pneumonia | 54 | 10 |
| Intermittent claudication | 42 | 1 |
| Atrial fibrillation | 37 | 10 |
| Coronary artery disease | 36 | 7 |
Showing 5 of 10 adverse events.
Which publications cover Plaque, Amyloid? (216)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Donanemab exposure-response in early symptomatic Alzheimer's disease. | Alzheimer's & dementia : the journal of the Alzheimer's Association | 2025 | Yes |
| Ferroptosis and pathogenesis of neuritic plaques in Alzheimer disease. | Pharmacological reviews | 2025 | Yes |
| Modified titration of donanemab reduces ARIA risk and maintains amyloid reduction. | Alzheimer's & dementia : the journal of the Alzheimer's Association | 2025 | Yes |
| TRAILBLAZER-ALZ 4: A phase 3 trial comparing donanemab with aducanumab on amyloid plaque clearance in early, symptomatic Alzheimer's disease. | Alzheimer's & dementia : the journal of the Alzheimer's Association | 2025 | Yes |
| The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology. | Alzheimer's & dementia : the journal of the Alzheimer's Association | 2025 | Yes |
Showing 5 of 216 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.