Condition (MeSH)
Prehypertension
ClinicalTrials.gov lists 158 trials for Prehypertension or a narrower condition beneath it. KGK Science Inc. has the most among industry and government lead sponsors, with 2.
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Trials per phase (log scale)
158 of the 158 trials are tagged with Prehypertension itself; the rest are tagged with a narrower condition beneath it.
When did Prehypertension trials start? (23)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 14
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 11 |
| 2025 | 2 |
| 2024 | 10 |
| 2023 | 4 |
| 2022 | 8 |
| 2021 | 6 |
| 2020 | 8 |
| 2019 | 3 |
| 2018 | 10 |
| 2017 | 7 |
Showing 10 of 23 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 12 trials starting in 2026 and about 7 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 22 months from start to primary completion across 9 trials still running at the 2026-10-09 snapshot; registered median of 23 months across 111 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Prehypertension trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 1/2 | 5 |
| Phase 2 | 10 |
| Phase 2/3 | 2 |
| Phase 3 | 9 |
| Phase 4 | 14 |
| Not applicable | 103 |
| Observational | 14 |
How many Prehypertension trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 8 |
| Recruiting | 10 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 3 |
| Completed | 96 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Prehypertension trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| KGK Science Inc. | 2 |
Which drugs are being tested for Prehypertension? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| NEBIVOLOL | 3 |
| Allisartan Isoproxil | 2 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Metoprolol XL | 3 |
| Allopurinol Pill | 2 |
| Amlodipine 5mg | 2 |
| Low Level Laser Therapy | 1 |
| Tbl amiloride | 1 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Prehypertension trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Very high blood pressure | 3 | 1 |
| Back Pain | 2 | 1 |
| Basal Cell Carcinoma | 1 | 1 |
| Exacerbation of depression | 1 | 1 |
| Grand Mal Seizure | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Prehypertension? (89)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Treatment of prehypertension among adults with HIV. | AIDS (London, England) | 2025 | Yes |
| Dietary management and aerobic exercise counselling on blood pressure control in subjects with prehypertension and drug-naïve stage 1 hypertension: a randomized clinical trial. | Scientific reports | 2025 | Yes |
| Effect of mindfulness-based interventions on people with prehypertension or hypertension: a systematic review and meta-analysis of randomized controlled trials. | BMC cardiovascular disorders | 2024 | Yes |
| Burden of noncommunicable diseases in Pakistan. | Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit | 2022 | Yes |
| Relaxing music reduces blood pressure and heart rate among pre-hypertensive young adults: A randomized control trial. | Journal of clinical hypertension (Greenwich, Conn.) | 2021 | Yes |
Showing 5 of 89 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.