Condition (MeSH)
Lipedema
ClinicalTrials.gov lists 80 trials for Lipedema or a narrower condition beneath it. Istanbul Physical Medicine Rehabilitation Training and Research Hospital has the most among industry and government lead sponsors, with 3.
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Trials per phase (log scale)
80 of the 80 trials are tagged with Lipedema itself; the rest are tagged with a narrower condition beneath it.
When did Lipedema trials start? (13)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 2
- Not applicable
- Observational
Top of scale: 11
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 21 |
| 2025 | 11 |
| 2024 | 11 |
| 2023 | 7 |
| 2022 | 7 |
| 2021 | 3 |
| 2020 | 3 |
| 2019 | 8 |
| 2018 | 3 |
| 2017 | 1 |
Showing 10 of 13 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 24 trials starting in 2026 and about 17 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Recruitment duration, a model prediction: 4 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Lipedema trials in? (4)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 2 | 3 |
| Not applicable | 35 |
| Observational | 41 |
| Expanded access | 1 |
How many Lipedema trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 12 |
| Recruiting | 13 |
| Enrolling by invitation | 2 |
| Active, not recruiting | 4 |
| Available | 1 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Lipedema trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Istanbul Physical Medicine Rehabilitation Training and Research Hospital | 3 |
| Caliway Biopharmaceuticals Co., Ltd. | 2 |
| Ankara Etlik City Hospital | 1 |
Which drugs are being tested for Lipedema? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| RZL-012 | 1 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Aerobic exercise | 2 |
| Exercise | 2 |
| Standard conservative treatment | 1 |
| NaCl 0.9% NS | 1 |
| NIRFLI with ICG | 1 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Lipedema? (62)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Effects of multimodal exercise program on edema, pain, exercise capacity, lower extremity muscle strength and function in patients with lipedema. | Phlebology | 2026 | Yes |
| Gastrointestinal hormones and subjective ratings of appetite after low-carbohydrate vs low-fat low-energy diets in females with lipedema - A randomized controlled trial. | Clinical nutrition ESPEN | 2025 | Yes |
| Adipose Tissue Biology and Effect of Weight Loss in Women With Lipedema. | Diabetes | 2025 | Yes |
| Defining lipedema's molecular hallmarks by multi-omics approach for disease prediction in women. | Metabolism: clinical and experimental | 2025 | Yes |
| Relationship Between 25-Hydroxyvitamin D and Vitamin B12 Levels and Neuropathic Pain in Patients Diagnosed with Lipedema. | Lymphatic research and biology | 2025 | Yes |
Showing 5 of 62 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.