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Condition (MeSH)

Hernias, Diaphragmatic, Congenital

ClinicalTrials.gov lists 86 trials for Hernias, Diaphragmatic, Congenital or a narrower condition beneath it.

MeSH D065630 Congenital / Hereditary / Neonatal C16 C23 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 1 Phase 2 Phase 2 6 Phase 3 Phase 3 4 Phase 4 Phase 4 2 Not applicable Not applicable 52 Observational Observational 20 Expanded access Expanded access 1 Phase 1 Phase 1 1 Phase 2 Phase 2 6 Phase 3 Phase 3 4 Phase 4 Phase 4 2 Not applicable Not applicable 52 Observational Observational 20 Expanded access Expanded access 1

Trials per phase (log scale)

86 of the 86 trials are tagged with Hernias, Diaphragmatic, Congenital itself; the rest are tagged with a narrower condition beneath it.

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When did Hernias, Diaphragmatic, Congenital trials start? (21)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 2
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 9

2002: 1 trials (Observational 1) 2005: 2 trials (Observational 1, Phase 3 1) 2007: 1 trials (Not applicable 1) 2008: 1 trials (Phase 2 1) 2009: 2 trials (Not applicable 1, Phase 2 1) 2010: 3 trials (Observational 2, Not applicable 1) 2012: 3 trials (Observational 1, Not applicable 2) 2013: 1 trials (Observational 1) 2014: 1 trials (Phase 2 1) 2015: 4 trials (Not applicable 4) 2016: 2 trials (Not applicable 2) 2017: 8 trials (Observational 2, Not applicable 4, Phase 2 2) 2018: 6 trials (Observational 1, Not applicable 4, Phase 1 1) 2019: 4 trials (Observational 2, Not applicable 1, Phase 3 1) 2020: 8 trials (Observational 1, Not applicable 7) 2021: 4 trials (Not applicable 4) 2022: 7 trials (Observational 3, Not applicable 3, Phase 2 1) 2023: 5 trials (Observational 2, Not applicable 3) 2024: 7 trials (Observational 1, Not applicable 6) 2025: 9 trials (Not applicable 5, Phase 4 2, Phase 3 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 6
2025 9
2024 7
2023 5
2022 7
2021 4
2020 8
2019 4
2018 6
2017 8

Forecast of the full-year count, planned starts included, not rows of this table: about 7 trials starting in 2026 and about 8 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 18 trials still running at the 2026-10-09 snapshot; registered median of 31 months across 32 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Hernias, Diaphragmatic, Congenital trials in? (7)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1
Phase 2 6
Phase 3 4
Phase 4 2
Not applicable 52
Observational 20
Expanded access 1

How many Hernias, Diaphragmatic, Congenital trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 5
Recruiting 30
Enrolling by invitation 2
Active, not recruiting 5
Completed 23

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Hernias, Diaphragmatic, Congenital? (1)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Autologous Umbilical Cord Blood 1

Interventions as named in the registry (8)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
data collection 2
Inhaled Nitric Oxide 1
Sildenafil Oral Suspension 1
Inhaled Milrinone 1
Bronchodilator Response 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Hernias, Diaphragmatic, Congenital trials report? (5)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Neonatal respiratory failure 6 1
Pneumothorax 3 1
Shock 3 1
Cardio-respiratory arrest neonatal 1 1
Haemorrhage intracranial 1 1

Which publications cover Hernias, Diaphragmatic, Congenital? (185)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Prevalence (66)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Congenital diaphragmatic hernia Prevalence at birth 1-5 / 10 000 United Kingdom GB Unspecified
Congenital diaphragmatic hernia Prevalence at birth 1-5 / 10 000 United Kingdom GB Exact
Congenital diaphragmatic hernia Prevalence at birth 1-5 / 10 000 United Kingdom GB Exact
Congenital diaphragmatic hernia Prevalence at birth 1-5 / 10 000 United States US Unspecified
Congenital diaphragmatic hernia Prevalence at birth 1-5 / 10 000 United States US Exact

Rare-disease identity (2)

Shown in this order: exact, broader, narrower, other.

Rare-disease identity
Orphanet disease ORPHA code Relation Source
Congenital diaphragmatic hernia 2140 Exact Orphanet Rare Disease Ontology (ORDO)
Congenital diaphragmatic hernia 2140 Exact Orphadata Science knowledge files, Product 1

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors and sub-conditions in mesh.

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