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Horizon Discovery Biosciences Limited
Horizon Discovery Biosciences Limited is listed as a mid sized business research supplier in the Scientist.com network, with 4 sites in 3 countries and 2 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Biomarkers
- Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
- Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
- Cell Line Construction Create new recombinant cell lines to exact specifications.
- Cell Lines Purchase culture reagents, cell lines and cellular material of any species. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have...
Show all 13 in Cell Culture and Characterization
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
- Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.
- Karyotyping Evaluate the number and appearance of chromosomes in the nucleus of a eukaryotic cell.
- RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
- Single Cell DNA Sequencing Examine genetic variations in a single cell.
- Viral Mediated Gene Delivery Use viral carriers to introduce new genetic material into a cell.
Show all 77 services
Clinical Consulting
- Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Discovery Chemistry
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Disease Models
- In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
DNA & RNA
- CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
- Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
- miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
- mRNA synthesis Transcribe mRNAs in vitro and add modifications such as polyadenylation and guanine capping.
- non-coding RNA Synthesis Prepare non-coding RNA in vitro.
- Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
Show all 19 in DNA & RNA
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
- RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
- RNA oligo synthesis Design and synthesize miRNAs, siRNAs and other non coding RNAs
- RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
- RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
- RNAi Pathway Analysis Use high-throughput RNAi genetic screens to elucidate relevant signaling pathways.
- shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
- Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
- siRNA Synthesis Produce high quality siRNAs for gene silencing studies.
- Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
- Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
- Whole Genome Sequencing Determine the entire genetic make-up of an organism.
Drug Development
- Bioinformatics Consulting Consulting Services for the science of collecting and analyzing complex biological data
- Target Validation Consulting Help to demonstrate that modification of target activity has potential therapeutic benefits.
Human Biological Samples
- Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...
- Human iPSC's For requesting human sourced induced pluripotent stem cells.
- Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
- Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
- Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...
In Vitro ADME
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- HTS Assay Development Develop assays to use in high throughput screening.
Show all 8 in In Vitro Assays
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
- Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Target Identification Identify the target(s) of a biologically active substance.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
- Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
In Vitro Toxicology
- ADCC and CDC Assay Services Measure toxicity of antibodies.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
- Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
- Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
- Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
- Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Oncology Models
- Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Scientific Data Services
- Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
- Mutation Data Profiling Guide treatment decisions in cancer based on the identification of genomic mutations .
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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United States 2 sites
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Austria 1 site
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United Kingdom 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Horizon Discovery is a UK Biotechnology company that combines a long scientific heritage in translational research with GENESIS™, a precision gene-editing platform that incorporates <acronym title="Recombinant Adeno-Associated Virus">rAAV</acronym>, <acronym title="Clustered Regularly Interspaced Short Palindromic Repeats">CRISPR</acronym> and <acronym title="Zinc Finger Nuclease">ZFN</acronym> technologies. The company supplies genetically-defined cell lines, gene-editing tools and services, custom cell line generation, reporter gene assay kits, molecular reference standards and assay...
Show the full description
Horizon Discovery is a UK Biotechnology company that combines a long scientific heritage in translational research with GENESIS™, a precision gene-editing platform that incorporates <acronym title="Recombinant Adeno-Associated Virus">rAAV</acronym>, <acronym title="Clustered Regularly Interspaced Short Palindromic Repeats">CRISPR</acronym> and <acronym title="Zinc Finger Nuclease">ZFN</acronym> technologies. The company supplies genetically-defined cell lines, gene-editing tools and services, custom cell line generation, reporter gene assay kits, molecular reference standards and assay development and screening services to approaching 1,000 organisations engaged in academic research; drug discovery and development, clinical diagnostics, and biopharmaceutical process optimization. Horizon aspires to provide science-driven research solutions that lead to advancement in the understanding of the genetic basis of disease and better outcomes for patients.
Read more about our X-MAN cell lines (X-MAN (Gene-X, Mutant And Normal) human isogenic disease models) including pricing
Browse the catalog of all available X-MAN cell lines
- Website
- www.horizondiscovery.com
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