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Quality Assistance

Quality Assistance is listed as a mid sized business research supplier in the Scientist.com network, with 1 site in 1 country and 2 service areas.

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Type of company: Mid sized business

Antibodies

AlphaLISA Quantification of analytes with high sensitivity, wider dynamic range and no wash steps involved.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
Immunodetection Use antibodies to identify a protein or antigen.

Biomarkers

Antimicrobial Effectiveness Testing Measure the efficacy of anti-microbial preservatives added to a product.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.

Show all 13 in Biomarkers 7 more

Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Peptide Bioanalysis Analyze the structure of Peptides.
Plaque Assays Determine infectious viral titer using plaque-forming units or purify viral stocks.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
Protein Glycosylation Mapping Technique Map glycosylation sites in proteins using liquid chromatography and mass spectrometry.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.

Show all 140 services 128 more

Cell Culture and Characterization

Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell Culture Culture primary or immortalized cell lines.
Cell Lines Purchase culture reagents, cell lines and cellular material of any species. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have...
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.

Chemical and Compound Analysis

Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Chemical Stability Measure the stability of small molecules in solution.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Circular Dichroism Examine the secondary structure and folding properties of proteins in solution.

Show all 38 in Chemical and Compound Analysis 32 more

Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Denaturing High Performance Liquid Chromatography Separate mixtures of denatured and reannealed oligos to identify single nucleotide substitutions, deletions and insertions.
Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Gas Chromatography Gas chromatography is an analytical technique that separates, identifies, and quantifies compounds in a mixture
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
Heavy Metals Analysis Ensure trace levels of heavy metals are below the maximum allowable limits for consumer safety.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
Liquid Chromatography Separate substances using a mobile and stationary phase.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
Photostability Measure drug degradation rates after exposure to various light sources.
Physicochemical Analysis Physicochemical Analysis of material or preparation evaluating (e.g.) particle size, composition, or compound structure.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Static Light Scattering Use scattered light intensity to determine the average molecular weight of biopolymers.
Structural Elucidation Determine chemical structure of a compound. Characterization techniques include mass spectrometry, infrared spectroscopy and X-ray crystallography.
Structural Spectroscopy Assess conformational transitions that proteins undergo in response to changes in their environment.
Viscosity Testing Evaluate the fluid flow properties of liquids for product evaluation and quality control.

Chemical and Compound Testing

Product Testing Ensure product quality standards are met.

Chemistry, Manufacturing and Controls (CMC)

Analytical Development and Validation Request services related to Analytical Development and Validation
API and Drug Product Stability Testing API and Drug Product Stability Testing.
API and Drug Product Storage and Distribution API and Drug Product Storage and Distribution.
API and drug product storage and release API and drug product storage and release
API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.

Show all 16 in Chemistry, Manufacturing and Controls (CMC) 10 more

API/DP specific test methods API/DP specific test methods (e.g., stability indicating HPLC assay and purity)
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Compendial test methods Run Compendial test methods (e.g., KF)
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Drug Substance and Drug Product Characterization and Manufacturing Drug Substance and Drug Product Characterization and Manufacturing.
Excipients Acquire synthetic or natural inert components to formulate therapeutic agents.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
ICH-compliant stability testing Perform ICH-compliant stability testing
Impurities in Drugs Risk Assessment Create a risk-based control strategy to determine any toxic elemental impurities that may be present in human medicines.
Thermo Scientific iCAP Q ICP-MS Expand your analytical capabilities with this complete trace elemental analysis solution for your high-throughput lab.

Clinical Trials

Statistical Analysis Planning Technical and detailed elaboration of the principal features of the analysis described in the protocol, and includes detailed procedures for executing the statistical analysis of the primary and secondary variables...

Discovery Chemistry

Certified Standards Find certified standards for assays, tests and services.
Extractable and Leachable Assessment Quantify potential impurities from container closures & packaging.
Leachable and extractable testing Leachable and extractable testing
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
USP Testing Analytical Reagents Acquire chemical reagents, solution concentrates and volumetric solutions used to evaluate items in USP testing.
USP-NF Grade Chemicals Acquire chemicals that comply with United States Pharmacopeia and National Formulary standards.

Show all 7 in Discovery Chemistry 1 more

UV and IR Profiling Analyze the integrity of a compound or large biomolecule.

DNA & RNA

Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
qPCR Analysis Measure the accumulation of PCR products in real time.
Restriction Fragment Length Polymorphism Identification Uses gel electrophoresis to identify differences in restriction fragment lengths produced by enzymatic digestion of DNA.

In Vitro ADME

Plasma Stability Assay Determine degradation rate of drug candidates in plasma.

In Vitro Assays

Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression

Show all 19 in In Vitro Assays 13 more

Cell Proliferation Measure cell number, cell viability and cell division.
ELISpot Assay and Testing Detect low levels of antigens.
Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Human Cell Assays Request in vitro human cells for assays
Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
Stem Cell Differentiation Microscopy Assay› Elucidate mechanisms of stem cell renewal and differentiation in vitro using fluorescence microscopy.
Thrombin Generation Tests Measure the tendency of a plasma sample to form thrombin upon the initiation of coagulation.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Other Specialty Toxicology

Residual DNA Analysis Measure contaminants found in therapeutics like biologicals and biosimilars that are produced in cells.
United States Pharmacopeia (USP) Testing Use USP standards to ensure quality of pharmaceuticals, supplements and food ingredients.

Protein Sciences

Carbohydrate Isolation Protocol Development Design and optimize protocols for carbohydrate isolation.
Carbohydrate Structure Characterization Use analytical tools to elucidate carbohydrate structure and physiochemical properties.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.

Show all 16 in Protein Sciences 10 more

LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Protein mapping Interrogate the entire sequence of a protein.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Products Find native and recombinant proteins and peptides.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Scientific Data Services

Data Lineage & Quality Track the various processes through which data has been created, edited or exchanged.
Data Quality Framework Manage data quality issues to maintain good quality data outputs.
NGS: Next Generation Sequencing Data Analysis Use software to interpret data created by RNA-Seq, DNA-Seq, ChIP-Seq and DNA methylation experiments.
Scientific Data Visualization Exploration and reporting of data by means of graphs and plots.
Scientific Pipeline Implementation Design, develop and deploy data analyses workflows.

Testing Services

Elevated Temperature Stability Determine the stability of a product at elevated temperature.
Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
Microbiological Sterility Testing Test the presence of viable microorganisms.
Package Compatibility Tests Ensure that the consumer product is not adversely affected by the package components and vice versa.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.

Other services

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Service areas:

Pharmacology Chemistry

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Quality Assistance offers ADME studies, drug efficacy, toxicological evaluation, CMC, clinical trials, and analytical services.

Website: www.quality-assistance.com

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