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Enamine

Enamine is listed as a mid sized business research supplier in the Scientist.com network, with 4 sites in 4 countries and 1 service area.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 4

Countries 4

Logo Enamine Ltd, via Wikimedia Commons, Public domain. Shown to identify the organization; it may be a registered trademark.

Type of company: Mid sized business

Agricultural Sciences Research & Development

General Agrochemical Compound Library Find potential compound candidates for agrochemical or agro-product research and development.

Antibodies

Custom Antibodies Design and produce polyclonal and monoclonal antibodies.

Bioimaging

Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.

Biomarkers

Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.

Cell Culture and Characterization

Cell Culture Culture primary or immortalized cell lines.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.

Chemical and Compound Analysis

Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
Chemical Stability Measure the stability of small molecules in solution.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.

Show all 12 in Chemical and Compound Analysis 6 more

NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
Protein Melting Point Analysis Assess protein stability by Differential Scanning Calorimetry (DSC) or Fluorimetry (Thermofluor) methods.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.

Show all 154 services 140 more

Chemistry, Manufacturing and Controls (CMC)

Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
Integrated Small Molecule Package Process an entire Small Molecule/Compounds Pipeline Project including: Compound Synthesis or Purchase, Compound Analysis/Testing, In Vitro Assays, and Formulation/Reformulation from our bundle of suppliers

Clinical Trials

Statistical Analysis Planning Technical and detailed elaboration of the principal features of the analysis described in the protocol, and includes detailed procedures for executing the statistical analysis of the primary and secondary variables...

Data Science/Bioinformatics

Discovery Compound Screening Analytics Screening of an entire compound library directly against the drug target or in a more complex assay.
Discovery Drug Response Simulation Analytics Simulation of how a drug responds in different environments, from molecular to population studies.
Discovery In Silico Proteome Analysis Used to understand the global protein environment, specifically drug-protein interactions.
Discovery Machine Learning/AI Complex analytical approaches to find patterns and make predictions in drug discovery projects.
Discovery Software Tools Software designed to serve the needs of discovery research groups.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Certified Standards Find certified standards for assays, tests and services.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Finding Service Enter the compound name, CAS # or SMILES string in the box below or upload an Excel, Word or SD file with a list of compounds.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.

Show all 31 in Discovery Chemistry 25 more

Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Purchase Consulting Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Pharmaceutical Research Chemicals Acquire chemicals that are prospective new drug entities.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
General Pain Models Measure therapeutic endpoints in animal models of general pain.

Show all 12 in Disease Models 6 more

Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
Morris Water Maze Investigate spatial learning and memory in rodents.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Chemoinformatics Consulting The use of computer and informational techniques applied to a range of problems in the field of chemistry.
Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.

General in vivo Toxicology

Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Short-Term Toxicity Tests Acquire preliminary data about the concentrations, exposure duration and effects of a toxin on organisms.
Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.

Show all 22 in In Vitro ADME 16 more

Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Reference Standards Find reference standards for assays, tests and services.

In Vitro Assays

Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.

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HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.

In Vitro Pharmacology

High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Mouse Efficacy Monotherapy Use mouse models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Show all 8 in In Vivo Pharmacokinetics 2 more

Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Custom Model Development Develop a custom disease model.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.

Nanotechnology

Nanoparticle Conjugation and Functionalization Modify biomolecules to enhance structure and function.

Oncology Models

Experimental Metastatic Models Measure therapeutic endpoints in animal models of experimental metastatic cancer.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Other Specialty Toxicology

Phototoxicity Determine whether drug treatment causes light-activated toxic effects.

Product Orders

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Protein Sciences

Fluorescence Polarization Investigate receptor-ligand interactions, protein-DNA interactions, proteolysis and membrane fluidity.
FRET/BRET Detect the location of proteins in living cells and their ability to interact with other proteins.
Protein Binding Determine drug-protein binding interactions
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.

Show all 8 in Protein Sciences 2 more

Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.

REACH Services

OECD 420: Acute Oral Toxicity - Fixed Dose Procedure A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use...
OECD 432: In Vitro 3T3 NRU Phototoxicity Test Test the cytotoxic effects of chemical substances and environmental samples on cell membranes.
OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.

Safety Pharmacology

Locomotor Activity Assessment Study - Rat Conduct a study to determine the psychostimulant or sedative activity or your compound in rats.

Scientific Data Services

Automated Image Analysis Automated Image Analysis
Machine Learning/ AI Predict and model an outcome (e.g. disease progression) based on input variables (i.e. features.)
Molecular Dynamics Software Run simulations that determine time-dependent behaviors of molecular systems.

Testing Services

Bacterial Reverse Mutation Assay Test whether a cosmetic product or ingredient causes DNA mutations in bacteria.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

Other services

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Service areas:

Chemistry

Germany Frankfurt am Main 1 site
Latvia Rīga 1 site
Ukraine Kyiv 1 site
United States Monmouth Junction 1 site

Enamine is a privately owned company with laboratories located in Kiev, Ukraine (Eastern Europe). We are “number 1” supplier of quality compound libraries for biological screening. Our stock collection is the biggest in the world approaching 2M compounds. All the compounds have been synthesized at Enamine hence guaranteed follow-up services in chemistry. Each year over 230k new compounds enter our stock collection. Our catalogue of building blocks contains 45k products and is increased by 1000 new compounds each month. Basing on our expertise in versatile fields of chemistry and many years...

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Basing on our expertise in versatile fields of chemistry and many years of experience in chemical synthesis and medicinal chemistry we provide services in custom synthesis, discovery chemistry, and lead optimization. The latter projects can be integrated with on-site biological screening and DMPK studies.

Website: www.enamine.net

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