- Supplier site
- Group of sites (click to zoom)
Scientist.com supplier network (site locations)
Research supplier
Translational Drug Development (TD2)
Translational Drug Development (TD2) is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 1 country and 4 service areas.
View Translational Drug Development (TD2) on Scientist.com
Email me this page as a PDF
Sign in to Scientist.com to open this supplier in your organization's marketplace.
Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Antibodies
- Antibody Therapy Efficacy In vivo assessment of monoclonal/bispecific antibody efficacy in a humanized mouse
- Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
- Immunodetection Use antibodies to identify a protein or antigen.
Bioimaging
- Bioimaging Visualize biological process non-invasively in real time.
- In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
- In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
- Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Biomarkers
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
- Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Show all 15 in Biomarkers
- Hematology CBC Run automated and manual complete blood cell counts (CBCs) as well as microscopic evaluations of cell types.
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
- Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
- Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Show all 89 services
Cell Culture and Characterization
- Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
- Human Melanoma Cell Lines Obtain highly characterized cell lines derived from patients’ tumors for in vitro and in vivo modelling.
- Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
Chemical and Compound Analysis
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Clinical Consulting
- Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
- Clinical Protocol Design & Development Creation of clinical protocol document which details how a clinical trial is designed, relating to to the methodology, hypothesis, and operation of clinical trial to ensure the safety of the patients is...
- Clinical Trial Consulting Consulting services for Clinical trials.
- Clinical Trial Feasibility Request services related to Clinical Trial Design and feasibility.
- Clinical Trial Recruitment Recruitment, enrollment and retention of patients for clinical trials.
- Regulatory Consulting Ensure that each product or device complies with all FDA rules and regulations.
Clinical Trials
- Clinical Trial Design Develop study-related protocols, case report forms (CRFs) and database tools for records management.
- Clinical Trial Risk Management Plan that maintains treatment quality throughout lifecycle and improve decision making.
- Investigator Recruitment Enlist clinical research experts to assist in investigator selection, recruitment monitoring and database evaluation.
- Nutraceuticals Clinical Research Trials Conduct clinical trials to test the efficacy and safety of nutraceuticals.
- Patient Recruitment Recruit and retain patients for clinical trials.
- Site Monitoring Maintain oversight over participant's health during a clinical trial.
Show all 7 in Clinical Trials
- Site Selection Select clinical trial sites with clinicians who recruit, enroll, treat and evaluate trial patients.
Disease Models
- Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
- In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
- Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
- Xenografts Evaluate drug candidate in tissue graft or organ transplant model.
DNA & RNA
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
Human Biological Samples
- Existing PDX models For requesting Existing PDX models
- Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
In Vitro ADME
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Pharmacology
- B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
- Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
- Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Show all 7 in In Vitro Pharmacology
- Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
In Vitro Toxicology
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
In Vivo Pharmacokinetics
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Mouse Efficacy Monotherapy Use mouse models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Medical Communications
- Protocol and Study Reports Write protocol and study reports, specifically relating to the drafting, writing, and editing of Clinical Safety Reports.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
- SCID/BG Mouse Use a single animal species to create one or more disease models for metastatic cancer.
Oncology Models
- CAR-T Efficacy In Vivo assessment of CAR-T and CAR-NK efficacy in a humanized mouse
- NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
- Nervous System PDX Patient derived xenografts relating to the components of the Nervous System. This includes PDX from the Brain, Spinal Cord, and Nerves.
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
- Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
- Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
Show all 8 in Oncology Models
- T11 (Breast Cancer) Measure therapeutic endpoints in animal models of breast cancer.
- Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.
Protein Sciences
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Regulatory Affairs
- Regulatory Submission Documents Request services related to the submission and writing of New Drug Applications (NDA), Investigational New Drugs (INDs), and Investigator Brochures (IB) to the FDA and other regulatory bodies.
- Risk Evaluation & Mitigation Strategy (REMS) Evidence required by FDA to support the benefit of treatment outweighs the risks. Purpose of REMS is to prevent, monitor, and manage serious risk by informing, educating, and reinforcing actions to reduce frequency...
Scientific Data Services
- Metabolomics Data Analysis Use metabolites to identify any potential biomarkers or novel therapeutic targets that may play a role in the mechanisms responsible for the progression of a disease.
Testing Services
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Other services
- 3D Vascularized Tumor Microenvironment Use microfluidic technology for the in vitro generation of living 3D perfused organ microenvironments.
- New Request
- Pfizer Sourcing Request Initiate a new request supported by a Pfizer Sourcing Group
Service areas:
Biology
Pharmacology
Toxicology
Clinical
Where it operates
Sites by country, with the cities in each.
-
United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Translational Drug Development (“TD2”) is an oncology drug development organization that has assisted over 400 small & mid-size biotech & pharmaceutical clients over the last decade, has transitioned over 30 compounds from nonclinical to clinical development & has managed over 65 Phase I - II clinical trials. TD2 has an integrated suite of tools, including more predictive preclinical models & cutting edge patient screening techniques & strategies that help in identifying the most responsive patient populations.
- Professional associations
- AZBio
- Website
- www.td2inc.com
Work with Translational Drug Development (TD2) on Scientist.com
For prices, more details, or to contact Translational Drug Development (TD2), visit Scientist.com.
Sign in to Scientist.com to open this supplier in your organization's marketplace.