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PolyCrystalLine SPA
PolyCrystalLine SPA is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 1 service area.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Bioimaging
- Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
- Scanning Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Chemical and Compound Analysis
- API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
- Chemical Stability Measure the stability of small molecules in solution.
- Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.
- Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
- Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
- Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Show all 15 in Chemical and Compound Analysis
- Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
- Photostability Measure drug degradation rates after exposure to various light sources.
- Protein Crystallization Create high quality protein-ligand crystals for x-ray diffraction studies.
- Scanning and Transmission Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
- Structural Chemistry Examine the relationship between protein structure and function.
- Structural Elucidation Determine chemical structure of a compound. Characterization techniques include mass spectrometry, infrared spectroscopy and X-ray crystallography.
- Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.
- X-Ray Fluorescence (XRF) Identify and quantify the elemental composition of solid and liquid samples.
Chemistry, Manufacturing and Controls (CMC)
- API and Drug Product Stability Testing API and Drug Product Stability Testing.
- API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
- API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
- API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Crystallization studies Crystallization studies
Show all 10 in Chemistry, Manufacturing and Controls (CMC)
- Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
- Raw Materials & Ingredients Purchase raw materials, ingredients, or chemicals for personal care, cosmetic, consumer health, and beauty products and substances.
- Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Show all 32 services
Discovery Chemistry
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Drug Development
- Structural Chemistry Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Protein Sciences
- X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.
Testing Services
- Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Service areas:
Where it operates
Sites by country, with the cities in each.
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Italy 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
PolyCrystalLine offers polymorph quantification, dissolution testing, stability screening, crystallization and structure determination services. Our extensive experience in solid-state systems has led our researchers to develop specific and flexible protocols for the study of crystalline forms. These can be adapted to meet the needs of the pharmaceutical industry and to solve any kind of issues related to APIs. All experiments are carried out manually by highly-trained researchers, thus avoiding the inaccuracies of mechanized tests (HTS). Screening protocols can also be carried out on high...
Show the full description
PolyCrystalLine offers polymorph quantification, dissolution testing, stability screening, crystallization and structure determination services.
Our extensive experience in solid-state systems has led our researchers to develop specific and flexible protocols for the study of crystalline forms. These can be adapted to meet the needs of the pharmaceutical industry and to solve any kind of issues related to APIs.
All experiments are carried out manually by highly-trained researchers, thus avoiding the inaccuracies of mechanized tests (HTS).
Screening protocols can also be carried out on high potent APIs.
- Website
- www.polycrystalline.it
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