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KaLy-Cell
KaLy-Cell is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 1 service area.
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Sites
1
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Agricultural Sciences Research & Development
- Method Development & Validation Engineer sensitive and selective methods that meet GLP validation requirements to access different agrochemical properties
Biomarkers
- Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
- Lipid Peroxidation Assay Use in vitro or in vivo assays to evaluate the effects of oxidative stress on lipid structure and function.
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Cell Culture Culture primary or immortalized cell lines.
Discovery Chemistry
- HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Disease Models
- Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
- Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
- LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
Show all 58 services
DNA & RNA
- qPCR Analysis Measure the accumulation of PCR products in real time.
- RNA Extraction Isolate total RNA or mRNA from cells or tissues
Human Biological Samples
- Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
- FRBESaHBS Request human biosamples including tissues, blood, serum, bone marrow, and tissue microarrays.
- HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
- HBS: Human Biological Samples - VMS Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
- Human Frozen Tissue For requesting frozen human tissue.
- Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...
In Vitro ADME
- Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
- Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
Show all 14 in In Vitro ADME
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
In Vitro Assays
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- Fully Automated Assays Develop and perform assays that require no manual steps
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
Show all 9 in In Vitro Assays
- In Vitro Human Cell Assays Request in vitro human cells for assays
- Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
- Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
In Vitro Pharmacology
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
- Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
- Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
- Reversibility Study Determine whether or not a compound inhibits an enzyme reversibly.
- Substrate Competitive Study Determine whether or not a compound is competitive with a substrate.
Show all 8 in In Vitro Pharmacology
- Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
- UDP-glucuronosyltransferases (UGT) Inhibition Assays Use biochemical, cell-based or in vivo assays to measure UDP-glucuronosyltransferase activity.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
In Vivo Pharmacokinetics
- Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
Other services
- Biological Material For requesting cells and other propagatable material.
- New Request
Service areas:
Toxicology
Where it operates
Sites by country, with the cities in each.
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France 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
KaLy-Cell provides products such as cryopreserved plateable hepatocytes from animal (rat/mouse/dog/monkey) and human origin.
Lots of human hepatocytes are :
- characterized for phase I metabolism and qualified for dose-response induction;
- qualified for high content assays
- qualified for transporters
- long-term repeat-toxicity assays
- cholestasis in vitro assay
KaLy-Cell provides services such as :
- induction studies (screening and regulatory)
- cytotoxicity tests, acute and repeat-toxicity
- Website
- www.kaly-cell.com
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